Search Results
Overview
| Uniprot ID | H0W1G1 |
|---|---|
| Protein Name | Telomeric repeat-binding factor 2-interacting protein 1 |
| Gene Name | TERF2IP |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 184 | PVSPSSQKLKRKAEQ |
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression
Protein Sequence
10
MAEAPQRPTH
20
SSTLFVRADG
30
NPLSFYVRPS
40
PIKRRLSTLI
50
LHGGGTVCGG
60
QEPGAVLLAQ
70
PGEALAEASG
80
DFISTQYILD
90
CVERNERLDL
100
EAYRLGRPPG
110
AEPQPPSGRV
120
AFTDADDVAI
130
LTYVKEHARS
140
PSSVTGNALW
150
KAMEKGALTQ
160
HSWQSMKDRY
170
LKHLRGQEHK
180
YLLGEAPVSP
190
SSQKLKRKAE
200
QDPEAADSGE
210
PQNKRTPDLP
220
EEEHVKEEIG
230
ENEETVKKIL
240
VETTRDFEEV
250
VVNESSDFEI
260
HLTMCDDDPP
270
TPEEDSETQL
280
DEEEEEKLSS
290
AEVGAAIKII
300
RQLMEKFNLD
310
LSTVTQAFLK
320
NSGELEATSS
330
FLESGRRADG
340
YPIWSRQDDL
350
DLQKDDEATR
360
DALVKKFGAQ
370
NVARRIEFRK
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0070187 | shelterin complex |
| Molecular Function | GO:0098505 | G-rich strand telomeric DNA binding |
| Molecular Function | GO:0019902 | phosphatase binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0048239 | negative regulation of DNA recombination at telomere |
| Biological Process | GO:0032205 | negative regulation of telomere maintenance |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0031848 | protection from non-homologous end joining at telomere |
| Biological Process | GO:0070198 | protein localization to chromosome, telomeric region |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0010569 | regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:0010833 | telomere maintenance via telomere lengthening |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.