Search Results
Overview
| Uniprot ID | H0W2Z8 |
|---|---|
| Protein Name | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
| Gene Name | CNP |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 177 | ADDLKKLKPGLEKDY |
Function
Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions
Protein Sequence
10
MSRGFSRKSH
20
ALLPKIFLRK
30
MSSTGARDKP
40
ELQFPFFQDE
50
ATVAALHECK
60
TLFILRGLPG
70
SGKSTLAQAI
80
VEKYRNGTKL
90
VSADAYKIMP
100
GPRAPFSEAY
110
KQLDEDLAAH
120
CRRDVRVLVL
130
DDTNHEPERL
140
EQLFDLADQY
150
QYQVLLVEPK
160
TAWRLDCAQL
170
KEKNQWQLSA
180
DDLKKLKPGL
190
EKDYLPLYFG
200
WFLTRKSSEA
210
LRKAGQVFLE
220
ELGNHKAFKK
230
ELRHFGPGDE
240
PREKLDLLAY
250
FGQRPPGVLH
260
CTTKFCNYGK
270
APGAEEYALQ
280
DAVKKAYGRA
290
FTLTISAFFV
300
TPKTVGARVE
310
LGEQELQLWP
320
NDVDKLSPSD
330
NLPRGSRAHI
340
TLGCAADVEP
350
VQTGLDLLEI
360
VRQEKGGSRG
370
EEVGELARGK
380
LLSLGSGRWV
390
LSLAKKVEAR
400
AIFTGYYGKG
410
KAVPTHSGRK
420
GGALQACALL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043209 | myelin sheath |
| Molecular Function | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0009214 | cyclic nucleotide catabolic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.