Search Results
Overview
| Uniprot ID | H0W316 |
|---|---|
| Protein Name | Peroxiredoxin-2 |
| Gene Name | PRDX2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | VTRTLSDKYGVLKRD |
| 196 | DSKEYFSKHH***** |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)
Protein Sequence
10
MASGSAHIGK
20
PAPDFTATAV
30
VDGAFKEVKL
40
SDFRGKYVVL
50
FFYPLDFTFV
60
CPTEIIAFSE
70
HAEDFRKLGC
80
EVLGVSVDSQ
90
FTHLAWINTP
100
RKEGGLGPLN
110
IPLLADVTRT
120
LSDKYGVLKR
130
DEGIAYRGLF
140
IIDGKGVLRQ
150
ITVNDLPVGR
160
SVEEALRLVQ
170
AFQYTDEHGE
180
VCPAGWKPGS
190
DTIKPTVDDS
KEYFSKHH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0008379 | thioredoxin peroxidase activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0002357 | defense response to tumor cell |
| Biological Process | GO:0042744 | hydrogen peroxide catabolic process |
| Biological Process | GO:0045321 | leukocyte activation |
| Biological Process | GO:0030194 | positive regulation of blood coagulation |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0019430 | removal of superoxide radicals |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.