Overview
| Uniprot ID | H0W3J6 |
|---|
| Protein Name | Polypyrimidine tract-binding protein 1 |
|---|
| Gene Name | PTBP1 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 401 |
PIRITLSKHQNVQLP |
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform
Protein Sequence
10
WGPSTLGRGS
20
DELFSTCVTN
30
GPFIMSSNSA
40
SAANGNDSKK
50
FKGDNRSTGV
60
PSRVIHIRKL
70
PGDVTEGEVI
80
SLGLPFGKVT
90
NLLMLKGKNQ
100
AFIEMNTEEA
110
ANTMVNYYTS
120
VPPVLRGQPI
130
YIQFSNHKEL
140
KTDSSPNQAR
150
AQAALQAVNS
160
VQSGNLALAA
170
SAAAVDAGLA
180
MAGQSPVLRI
190
IVENLFYPVT
200
LDVLHQIFSK
210
FGTVLKIITF
220
TKNSQFQALL
230
QYADPVSAQH
240
AKLSLDGQNI
250
YNACCTLRID
260
FSKLTSLNVK
270
YNNDKSRDYT
280
RPDLPSGDSQ
290
PSLDQTMAAA
300
FGLSVPNVHG
310
ALAPLAIPSA
320
AAAAAAAGRI
330
GIPGLAGAGN
340
SVLLVSNLNP
350
EPCPRWAFEG
360
VYGDVQRVKI
370
LFNKKENALV
380
QMADGSQAQL
390
AMSHLNGHKL
400
HGKPIRITLS
410
KHQNVQLPRE
420
GQEDQGLTKD
430
YGNSPLHRFK
440
KPGSKNFQNI
450
FPPSATLHLS
460
NIPPSISEED
470
LKSLFSSNGG
480
VVKGFKFFQK
490
DRKMALIQMG
500
SVEEAVQALI
510
DLHNHDLGEN
520
HHLRVSFSKS
TI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:1903312 |
negative regulation of mRNA metabolic process |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.