Overview
| Uniprot ID | H0W511 |
|---|
| Protein Name | COP9 signalosome complex subunit 4 |
|---|
| Gene Name | COPS4 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
MNSSGSHKDLAGKYR |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Protein Sequence
10
MAAAVRQDLA
20
QLMNSSGSHK
30
DLAGKYRQIL
40
EKAVQLSGAE
50
QLEALKAFVE
60
AMVNENVSLV
70
ISRQLLTDFC
80
THLPNLPDST
90
AKEIYHFTLE
100
KIQPRVISFE
110
EQQYNVDYKL
120
ETYLKIARLY
130
LEDDDPVQAE
140
AYINRASLLQ
150
NESTNEQLQI
160
HYKVCYARVL
170
DYRRKFIEAA
180
QRYNELSYKT
190
IVHESERLEA
200
LKHALHCTIL
210
ASAGQQRSRM
220
LATLFKDERC
230
QQLAAYGILE
240
KMYLDRIIRG
250
NQLQEFAAML
260
MPHQKATTAD
270
GSSILDRAVI
280
EHNLLSASKL
290
YNNITFEELG
300
ALLEIPAAKA
310
EKIASQMITE
320
GRMNGFIDQI
330
DGIVHFETRE
340
ALPTWDKQIQ
350
SLCFQVNNLL
360
EKISQTAPEW
370
TAQAMEAQMA
Q
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Biological Process |
GO:0000338 |
protein deneddylation |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.