Overview
| Uniprot ID | H0W641 |
|---|
| Protein Name | Protein SET |
|---|
| Gene Name | LOC100732059 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 14 |
SLLTPPTKKARQSPG |
| 23 |
ARQSPGPKAASASPG |
| 33 |
SASPGLPKGEKEQQE |
Function
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher
Protein Sequence
10
MAPKRQSLLT
20
PPTKKARQSP
30
GPKAASASPG
40
LPKGEKEQQE
50
AIEHIDEVQN
60
EIDRLNEQAS
70
EEILKVEQKY
80
NKLRQPFFQK
90
RSELIAKIPN
100
FWVTTFVNHP
110
QVSALLGEED
120
EEALHYLTRV
130
EVTEFEDIKS
140
GYRIDFYFDE
150
NPYFENKVLS
160
KEFHLNENGD
170
PSSKSTEIKW
180
KSGKDLTKRS
190
SQTQNKASRK
200
RQHEEPESFF
210
TWFTDHSDAG
220
ADELGEVIKD
230
DIWPNPLQYY
240
LVPDMDDEEG
250
EGEEDDDDDE
260
EEEGLEDIDE
270
EGEEDEGEED
280
EDDDGEEGEE
DEGEDD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Biological Process |
GO:0006334 |
nucleosome assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.