Overview
| Uniprot ID | H0W6W3 |
|---|
| Protein Name | Anamorsin |
|---|
| Gene Name | CIAPIN1 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 190 |
GKKRKACKNCTCGLA |
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells
Protein Sequence
10
GISAGQLVAV
20
IWDKSTPTEA
30
LKDLVDKLQG
40
LTGSEDRVSV
50
ENIDQLLQFN
60
NSKMKTASKL
70
CSALTLSGLV
80
EVKELQREPL
90
SPGEVKSVQE
100
HLGYNNNSLL
110
IIQITGKKPN
120
FEVGSSSQLN
130
LSIIKKPSVK
140
PAVDPAAAKL
150
WTLSANDMED
160
EGMDLIDSDE
170
LLDPEDLKKP
180
DPASLRAASC
190
GEGKKRKACK
200
NCTCGLAEEL
210
EKEKSEAQKS
220
SQPKSACGNC
230
YLGDAFRCAS
240
CPYLGMPAFK
250
PGEKVLLSNS
SLHDA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005758 |
mitochondrial intermembrane space |
| Cellular Component |
GO:0005730 |
nucleolus |
| Molecular Function |
GO:0051537 |
2 iron, 2 sulfur cluster binding |
| Molecular Function |
GO:0051539 |
4 iron, 4 sulfur cluster binding |
| Molecular Function |
GO:0009055 |
electron transfer activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0030097 |
hemopoiesis |
| Biological Process |
GO:0016226 |
iron-sulfur cluster assembly |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.