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Overview

Uniprot IDH0W7I1
Protein NameAdenine phosphoribosyltransferase
Gene NameAPRT
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
91 VLIRKRGKLPGPTVS

Function

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

Protein Sequence

10 MADSELQLVS 20 RRIRSFPDFP 30 IPGVNFRDIS 40 PLLKDPESFR 50 TSIRLLAGHL 60 KTAHGGKIDY 70 IAGLDSRGFL 80 FGPSLAQELG 90 LGCVLIRKRG 100 KLPGPTVSTS 110 YALEYGKAEL 120 EIQKDALEPG 130 QKVVVVDDLL 140 ATGGTMCAAC 150 ELLGQLGAEV 160 LECVTLVELT 170 SLKGREKLGP 180 VPFFSLLQYE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0002055 adenine binding
Molecular Function GO:0003999 adenine phosphoribosyltransferase activity
Molecular Function GO:0016208 AMP binding
Biological Process GO:0006168 adenine salvage
Biological Process GO:0044209 AMP salvage
Biological Process GO:0032264 IMP salvage
Biological Process GO:0006166 purine ribonucleoside salvage

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.