Overview
| Uniprot ID | H0W849 |
|---|
| Protein Name | Coatomer subunit delta |
|---|
| Gene Name | ARCN1 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 233 |
LKLGAKGKEVDNFVD |
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors
Protein Sequence
10
MVLLAAAVCT
20
KAGKAIVSRQ
30
FVEMTRTRIE
40
GLLAAFPKLM
50
NTGKQHTFVE
60
TESVRYVYQP
70
MEKLYMVLIT
80
TKNSNILEDL
90
ETLRLFSRVI
100
PEYCRALEEN
110
EISEHCFDLI
120
FAFDEIVALG
130
YRENVNLAQI
140
RTFTEMDSHE
150
EKVFRAVRET
160
QEREAKAEMR
170
RKAKELQQAR
180
RDAERQGKKA
190
PGFGGFGSSA
200
VSGGSTAAMI
210
TETIIETDKP
220
KVAPAPARPS
230
GPSKALKLGA
240
KGKEVDNFVD
250
KLKSEGETIM
260
SSNMGRRTSE
270
TTKVHAPPIN
280
MESVHMKIEE
290
KITLTCGRDG
300
GLQNMELHGM
310
IMLRISDDKF
320
GRIRLHVENE
330
DKKGVQLQTH
340
PNVDKKLFTS
350
ESLIGLKNPE
360
KSFPVNSDVG
370
VLKWRLQTTE
380
ESFIPLTINC
390
WPSESGNGCD
400
VNIEYELQED
410
NLELNDVVIT
420
IPLPSGVGAP
430
VIGEIDGEYR
440
HDSRRNTLEW
450
CLPVIDAKNK
460
SGSLEFSIAG
470
QPNDFFPVQV
480
SFISKKNYCN
490
IQVTKVTQVD
500
GNSPVRFSTE
510
TTFLVDKYEI
L
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030126 |
COPI vesicle coat |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Biological Process |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process |
GO:0051645 |
Golgi localization |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.