Search Results
Overview
| Uniprot ID | H0W865 |
|---|---|
| Protein Name | Histone H4 |
| Gene Name | LOC134478524 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 32 | DNIQGITKPAIRRLA |
| 78 | VTYTEHAKRKTVTAM |
| 80 | YTEHAKRKTVTAMDV |
| 92 | MDVVYALKRQGRTLY |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein Sequence
10
MSGRGKGGKG
20
LGKGGAKRHR
30
KVLRDNIQGI
40
TKPAIRRLAR
50
RGGVKRISGL
60
IYEETRGVLK
70
VFLENVIRDA
80
VTYTEHAKRK
90
TVTAMDVVYA
100
LKRQGRTLYG
FGG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.