Search Results
Overview
| Uniprot ID | H0W9D3 |
|---|---|
| Protein Name | Glutathione S-transferase |
| Gene Name | GSTP1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | YATLIYTKYEEGKSD |
| 116 | YTKYEEGKSDYVKAL |
| 121 | EGKSDYVKALPGHLK |
| 43 | MESWMQGKLKASCLY |
| 45 | SWMQGKLKASCLYGQ |
| 82 | RSLGLYGKDQREAAL |
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Protein Sequence
10
MAPYTIVYFP
20
VRGRCEAIRM
30
LLADQGQTWK
40
EEVVTMESWM
50
QGKLKASCLY
60
GQLPKFLDGD
70
LTLYQSNAIL
80
RHLGRSLGLY
90
GKDQREAALV
100
DMVNDGVEDL
110
RCKYATLIYT
120
KYEEGKSDYV
130
KALPGHLKPF
140
ETLLSQSQGG
150
KAFIMGDQIS
160
FADYNLLDLL
170
LIHQVLAPSC
180
LDDFPLLSAY
190
VARLTARPKL
200
KAFLASSDHV
210
NRPINGNGKQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0097057 | TRAF2-GSTP1 complex |
| Molecular Function | GO:0035731 | dinitrosyl-iron complex binding |
| Molecular Function | GO:0005504 | fatty acid binding |
| Molecular Function | GO:0004602 | glutathione peroxidase activity |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0035730 | S-nitrosoglutathione binding |
| Biological Process | GO:1901687 | glutathione derivative biosynthetic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0051122 | hepoxilin biosynthetic process |
| Biological Process | GO:0043651 | linoleic acid metabolic process |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:0110076 | negative regulation of ferroptosis |
| Biological Process | GO:0032691 | negative regulation of interleukin-1 beta production |
| Biological Process | GO:0046329 | negative regulation of JNK cascade |
| Biological Process | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production |
| Biological Process | GO:0032720 | negative regulation of tumor necrosis factor production |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.