Overview
| Uniprot ID | H0W9H4 |
|---|
| Protein Name | Myc box-dependent-interacting protein 1 |
|---|
| Gene Name | BIN1 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 156 |
KDEAKIAKPVSLLEK |
Function
Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation
Protein Sequence
10
MAEMGSKGVT
20
AGKIASNVQN
30
KLTRAQEKVK
40
KTKTERVQTE
50
GTRLQKDLRT
60
YLASVKAMHE
70
ASKKLNECLQ
80
EVYEPDWPGR
90
EEASKIAENN
100
DLLWMDYHQK
110
LVDQALLTMD
120
TYLGQFPDIK
130
SRIAKRGRKL
140
VDYDSARHHY
150
ESLQTAKKKD
160
EAKIAKPVSL
170
LEKAAPQWCQ
180
GKLQAHLVAQ
190
TNLLRNQAEE
200
ELIKAQKVFE
210
EMNVDLQEEL
220
PSLWNSRVGF
230
YVNTFQSIAG
240
LEENFHKEMS
250
KLNQNLNDVL
260
VSLEKQHGSN
270
TFTVKAQPSD
280
NAPAKGNKSP
290
SPPPDGSPAA
300
TPEIRVNHEP
310
EPASGATPGA
320
TIPKSPSQLR
330
KGPPVPPPPK
340
HTPSKEVKQE
350
QILSLFDDTF
360
VPEISVTTPS
370
QFEAPGPFSE
380
QASLLDLDFD
390
PIPPVASPVK
400
APTPSGQSIP
410
WDLWEPTESP
420
AGSRPSGEPS
430
VAEGTFAVSW
440
PSQTAEPGPA
450
QPAEASEVAG
460
GNQPAAGAQE
470
PGETAASEAA
480
SSSLPAVVVE
490
TFSATVNGTV
500
EGGSGAGRLD
510
LPPGFMFKVQ
520
AQHDYTATDT
530
DELQLKAGDV
540
VLVIPFQNPE
550
EQDEGWLMGV
560
KESDWNQHKE
570
LEKCRGVFPE
NFTERVQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0060987 |
lipid tube |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Cellular Component |
GO:0030315 |
T-tubule |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0019828 |
aspartic-type endopeptidase inhibitor activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005543 |
phospholipid binding |
| Molecular Function |
GO:0002020 |
protease binding |
| Molecular Function |
GO:0051087 |
protein-folding chaperone binding |
| Molecular Function |
GO:0070063 |
RNA polymerase binding |
| Molecular Function |
GO:0048156 |
tau protein binding |
| Biological Process |
GO:0008333 |
endosome to lysosome transport |
| Biological Process |
GO:0060988 |
lipid tube assembly |
| Biological Process |
GO:1902430 |
negative regulation of amyloid-beta formation |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006997 |
nucleus organization |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:0048711 |
positive regulation of astrocyte differentiation |
| Biological Process |
GO:0010564 |
regulation of cell cycle process |
| Biological Process |
GO:0030100 |
regulation of endocytosis |
| Biological Process |
GO:0045664 |
regulation of neuron differentiation |
| Biological Process |
GO:0048488 |
synaptic vesicle endocytosis |
| Biological Process |
GO:0033292 |
T-tubule organization |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.