Search Results
Overview
| Uniprot ID | H0WA12 |
|---|---|
| Protein Name | Endothelial differentiation-related factor 1 |
| Gene Name | EDF1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 135 | IGLKLRGKDIGKPIE |
| 143 | DIGKPIEKGPRAK** |
| 25 | TAAQAKSKQAILAAQ |
| 50 | KWAAGQNKQHSITKN |
Function
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism
Protein Sequence
10
MAESDWDTVT
20
VLRKKGPTAA
30
QAKSKQAILA
40
AQRRGEDVET
50
SKKWAAGQNK
60
QHSITKNTAK
70
LDRETEELHH
80
DRVTLEVGKV
90
IQRGRQSKGL
100
TQKDLATKIN
110
EKPQVIADYE
120
SGRAIPNNQV
130
LGKIERAIGL
140
KLRGKDIGKP
IEKGPRAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0001094 | TFIID-class transcription factor complex binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003677 | DNA binding |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.