Overview
| Uniprot ID | H0WAR7 |
|---|
| Protein Name | Methylosome protein WDR77 |
|---|
| Gene Name | WDR77 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 3 |
*****MRKETPPPLV |
Function
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage
Protein Sequence
10
MRKETPPPLV
20
PPAAREWNLP
30
PNAPACMERQ
40
LEAARYRSDG
50
ALLLGASSLS
60
GRCWAGSLWL
70
FKDPCAAPNE
80
GFCSAGVQTE
90
AGVADLTWVG
100
DRGILVASDS
110
GAVELWELDE
120
NETLIVSKFC
130
KYEHDDIVST
140
VGVLSSGTQA
150
VSGSKDFCIK
160
IWDLTQQMVL
170
NSYRAHAGQV
180
TCVAASPHKD
190
SMFLSCSEDS
200
RILLWDTRCP
210
KPASQMGCNA
220
SGYLPTSLAW
230
HPQQNEVFVF
240
GDENGTVSLV
250
DIKSASCALS
260
SAVHTQCVTR
270
LVFSPHSIPF
280
LASLSEDCSL
290
AVLDSSLSEV
300
FRSRAHRDFV
310
RDATWSPLNH
320
SLLTTVGWDH
330
QVIHHIVPIE
340
PVSDLRPEST
AK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031465 |
Cul4B-RING E3 ubiquitin ligase complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0034709 |
methylosome |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0008327 |
methyl-CpG binding |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Molecular Function |
GO:1990756 |
ubiquitin-like ligase-substrate adaptor activity |
| Biological Process |
GO:0007309 |
oocyte axis specification |
| Biological Process |
GO:0000209 |
protein polyubiquitination |
| Biological Process |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.