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Overview

Uniprot IDH0WBB5
Protein NameATP-dependent 6-phosphofructokinase
Gene NamePFKL
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
363 YKLLAHQKVSKEKTN
648 FDRNYGTKLGVKAML

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway

Protein Sequence

10 MNAAVRAVTR 20 MGIYVGAKVF 30 LIYEGYEGLV 40 EGGENIKPAT 50 WLSVSNIIQL 60 GGTIIGSARC 70 QAFTTREGRR 80 AAAYNLVQRG 90 ITNLCVIGGD 100 GSLTGANIFR 110 SEWGGLLEEL 120 VREGKISETT 130 AQTYSHLNIA 140 GLVGSIDNDF 150 CGTDMTIGTD 160 SALHRIMEVI 170 DAITTTAQSH 180 QRTFVLEVMG 190 RHCGYLALVS 200 ALASGADWLF 210 IPEAPPEDGW 220 ENFMCERLGE 230 TRSRGSRLNI 240 IIIAEGAIDR 250 HGKPISSSYV 260 KDLVVQRLGF 270 DTRVTVLGHV 280 QRGGTPSAFD 290 RILSSKMGIE 300 AVMALLEATP 310 DTPACVVSLS 320 GNQSVRLPLM 330 ECVQVTKDVQ 340 KAMDDRRFEE 350 AIQLRGRSFE 360 NNWNIYKLLA 370 HQKVSKEKTN 380 FSLAILNVGA 390 PAAGMNAAVR 400 SAVRTGISQG 410 HTVYVVHDGF 420 EGLAKGQVQE 430 VGWHDVAGWL 440 GRGGSMLGTK 450 RTLPKGHMEA 460 IVENLRAHNI 470 HALLVIGGFE 480 AYEGVLQLVE 490 ARGRYEELCI 500 VMCVIPATIS 510 NNVPGTDFSL 520 GSDTAVNAAM 530 ESCDRIKQSA 540 SGTKRRVFIV 550 ETMGGYCGYL 560 ATVTGIAVGA 570 DAAYVFEDPF 580 NIHDLEANVE 590 HMTEKMKTDI 600 QRGLVLRNEK 610 CHEHYTTEFL 620 YNLYSSEGKG 630 VFDCRTNVLG 640 HLQQGGAPTP 650 FDRNYGTKLG 660 VKAMLWMSDK 670 LQAVYRKGRV 680 FANAPDSACV 690 IGLRKKVVAF 700 SPVTELKEDT 710 DFEHRMPREQ 720 WWLNLRLMLK 730 MLAHYHISMA 740 DYVSGELEHV 750 TRRTLSLDTG F

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005945 6-phosphofructokinase complex
Cellular Component GO:0016020 membrane
Molecular Function GO:0003872 6-phosphofructokinase activity
Molecular Function GO:0016208 AMP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0070061 fructose binding
Molecular Function GO:0070095 fructose-6-phosphate binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0030388 fructose 1,6-bisphosphate metabolic process
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0009749 response to glucose

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.