Search Results
Overview
| Uniprot ID | H0WBZ0 |
|---|---|
| Protein Name | SUMO-activating enzyme subunit 1 |
| Gene Name | SAE1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 184 | EEKTKVAKVSQGVED |
| 196 | VEDGPDTKRAKLDSS |
| 199 | GPDTKRAKLDSSETT |
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2
Protein Sequence
10
GRVAASARRE
20
AAQYDRQIRL
30
WGLEAQKTVR
40
AVVALRASRV
50
LLVGMKGLGA
60
EIAKNLILAG
70
VKGLTMLDHE
80
QVSPDDPGAQ
90
FLIRTGSIGR
100
NRAEASLERA
110
QNLNPMVDVK
120
VDTEDIEKKP
130
ESFFTQFDAV
140
CLTCCSRDVI
150
VKVDQICHKN
160
SIKFFTGDVF
170
GYHGYTFANL
180
GEHEFVEEKT
190
KVAKVSQGVE
200
DGPDTKRAKL
210
DSSETTMVKK
220
KVVFCPVKEA
230
LEVDWSSEKA
240
KAALKRTTSD
250
YFLLQVLLKF
260
RTDKGRDPGS
270
DTYGEDSELL
280
LHIRNDVLDS
290
LGVSPDLLPD
300
DFVRYCFSEM
310
APVCAVVGGI
320
LAQEIVKALS
330
QRDPPHNNFF
340
FFDGMKGNGI
VECLGPK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0031510 | SUMO activating enzyme complex |
| Molecular Function | GO:0043008 | ATP-dependent protein binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0044388 | small protein activating enzyme binding |
| Molecular Function | GO:0019948 | SUMO activating enzyme activity |
| Biological Process | GO:0033235 | positive regulation of protein sumoylation |
| Biological Process | GO:0016925 | protein sumoylation |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.