Search Results

Overview

Uniprot ID	H0WC63
Protein Name	Tight junction protein 2
Gene Name	TJP2
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
277	GVLLTKSKANEEYGL

Function

Plays a role in tight junctions and adherens junctions. Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity

Protein Sequence

10 MEELKWEQYT 20 VTLQKDSKRG 30 FGIAVSGGRD 40 NPHFENGETS 50 IVISDVLPGG 60 PADGLLKEND 70 RVVMVNGTSM 80 EGVLHSFAVQ 90 QLRKSGKVAA 100 IVVKRPRIVQ 110 VAPLQGSPAL 120 SHDDRAFDVM 130 DELDNRSYRS 140 GYSERSPHGS 150 REEFHRSWEG 160 SLDRGRGHHR 170 YQDQDRSRGQ 180 SLERGLDRDD 190 RRARDRSRGR 200 SVDRDYDRDY 210 DRDYERSYEQ 220 DYERSHRPAY 230 GKDSPSSGNR 240 RQVQPESRYE 250 RPRSRSQEHF 260 QSHSPSPEPR 270 GQPASDGHIG 280 VLLTKSKANE 290 EYGLRLGSQI 300 FIKEMTKTGL 310 ASKDGNLHEG 320 DLVLKINGTV 330 TENMSLIDAG 340 KLIEKSRGKL 350 QLVVFRDSKQ 360 TLINIPSLND 370 SDSELEDISE 380 MESVRSFSPE 390 ERRQQYSDYD 400 YHSSNEKLKE 410 RRSSREDAPP 420 GRLSRMGATP 430 TPFKASGDSA 440 AVATETKKEP 450 RSQEEPPAPL 460 PRTTPRTFLR 470 PSPEDEAIYG 480 PDTKMVKFKK 490 GDSVGLRLAG 500 GNDVGLFVAG 510 IQEGTAAEEA 520 GLQEGDQILK 530 VNTQDFRGLV 540 REDAVLYLLE 550 IPKGDMVTIL 560 VQSRADVYRD 570 ILACGRGDSF 580 FIRAHFECEK 590 ESPQSLAFSR 600 GEVFRVVDTL 610 YDGKLGHWLA 620 VRIGNELEKG 630 LIPNRSRAEQ 640 MASVQNGQRD 650 NAGDRADFWR 660 MRGQRSGAKK 670 NLRKSREDLT 680 AAVSVSTKFP 690 AYERVLLREA 700 GFKRPVVLFG 710 PIADVAMEKL 720 TNELPDLFQT 730 AKTEPKDAGS 740 EKSTGVVRLN 750 TVRQIIEQDK 760 HALLDVTPKA 770 VDLLNYTQWF 780 PIVIFFNPDS 790 RQGVKIMRQR 800 LNPSSNKSSR 810 KLYDQANKLK 820 KTCAHLFTAT 830 INLNSANDSW 840 FGSLKDTIQN 850 QQGQAVWVSE 860 GKIEGMDDDP 870 DDHMSYLTAL 880 GADYLSCDSR 890 LISDFEDTDG 900 EGGAYTDNEL 910 DEPAEEPLVS 920 SITRSSEPVQ 930 HEESIRKLSP 940 EPPAQMRRAA 950 SRDQLRDSSP 960 PPAFKPEPPK 970 IKPQNREESY 980 DFSKSQEYKG 990 CPPPVAAKPS 1000 FGRSVQKPSV 1010 PVPAPESEEV 1020 EERIEDQENA 1030 PKSVLGKVKI 1040 FEKMDHKARL 1050 QRLQELQEAQ 1060 NAQIEIAQKH 1070 PSIYAVPIKA 1080 PKPDAGLPQH 1090 TSSRPPEPQK 1100 GPSRFSQNMH 1110 GSYGSDAEEE 1120 EYRQQLAEHS 1130 KRSYFGQPAK YRDTEL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005923	bicellular tight junction
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0050839	cell adhesion molecule binding
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0045216	cell-cell junction organization
Biological Process	GO:0090557	establishment of endothelial intestinal barrier
Biological Process	GO:1905605	positive regulation of blood-brain barrier permeability
Biological Process	GO:0150105	protein localization to cell-cell junction

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.