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Overview

Uniprot ID	H0WCG1
Protein Name	YTH domain-containing family protein
Gene Name	YTHDC1
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
132	AYKSQPEKTCLRKRD
82	SSSVSNNKRIVSTKG
88	NKRIVSTKGKPVTEY

Function

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing

Protein Sequence

10 MAADSREEKD 20 GELNVLDDIL 30 TEVPEQDDEL 40 YNPESEQDKN 50 EKKGSKRKSD 60 RMESTDAKRQ 70 KPSIHSRQLI 80 SKPLSSSVSN 90 NKRIVSTKGK 100 PVTEYKNEEY 110 QRSERSKRLD 120 TDRKIRLSSS 130 ASREAYKSQP 140 EKTCLRKRDP 150 ERRAKSPTPD 160 VSERIGLEVD 170 RRASRSSQSS 180 KEEVNSEEYG 190 SDHETGSSGS 200 SDEQGNNTEN 210 EEEGVEEDVE 220 EEEEVEEDAE 230 EEEEVDEEGE 240 EEEEEEEEEE 250 EEEEEEEEEY 260 EQDERDQKEE 270 GNDYDTRSEA 280 SDSGSESVSF 290 TDGSVRSGSG 300 TDGSDEKKKE 310 RKRARGISPI 320 VFDRSGSSAS 330 ESYADQTSKL 340 KYVLQDARFF 350 LIKSNNHENV 360 SLAKAKGVWS 370 TLPVNEKKLN 380 LAFRSARSVI 390 LIFSVRESGK 400 FQGFARLSSE 410 SHHGGSPIHW 420 VLPAGMSAKM 430 LGGVFKIDWI 440 CRRELPFTKS 450 AHLTNPWNEH 460 KPVKIGRDGQ 470 EIELECGTQL 480 CLLFPPDESI 490 DLYQLIHKMR 500 HKRRMHSQPR 510 SRGRPSRREP 520 VRDVGRRRPE 530 DYDIHNSRKK 540 PRIDYPPEFH 550 QRPPPYPGLE 560 QPPHHPYYQH 570 HAPPPQAHPP 580 YSGHHAVPHE 590 ARYRDKRVHD 600 YDMRVDDFLR 610 RTQAVVSGRR 620 SRPRERDRER 630 ERDRPRDNRR 640 DRERDRGRDR 650 ERERERLCDR 660 DRDRGERGRY RR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:1990247	N6-methyladenosine-containing RNA reader activity
Biological Process	GO:0000398	mRNA splicing, via spliceosome
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.