Search Results
Overview
| Uniprot ID | H0WD22 |
|---|---|
| Protein Name | - |
| Gene Name | VAPB |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 181 | IISTTASKTEAPSVS |
Function
Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner. Via interaction with WDR44 participates in neosynthesized protein export. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation
Protein Sequence
10
MRLRTSREGL
20
GAQPPSLPWS
30
WRRAPLPAAR
40
DRPAAACVRA
50
SLRACVRAPF
60
YSAGPFTDVV
70
TTNLKLGNPT
80
DRNVCFKVKT
90
TAPRRYCVRP
100
NSGIIDAGAS
110
INVSVMLQPF
120
DYDPNEKSKH
130
KFMVQSMFAP
140
ADTSDMEAVW
150
KEAKPEDLMD
160
SKLRCVFELP
170
AENDKPHDVE
180
INKIISTTAS
190
KTEAPSVSKS
200
LTSSLDDTEV
210
KKVMEECKRL
220
QGEVQRLREE
230
NRQFKEEDGL
240
RMRKTAQSHG
250
PIAALAAAGK
260
EEGLSTRLLA
270
LVVLFFIVGV
IIGKIAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0033149 | FFAT motif binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0030301 | cholesterol transport |
| Biological Process | GO:0090114 | COPII-coated vesicle budding |
| Biological Process | GO:0090158 | endoplasmic reticulum membrane organization |
| Biological Process | GO:0061817 | endoplasmic reticulum-plasma membrane tethering |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0036498 | IRE1-mediated unfolded protein response |
| Biological Process | GO:0045070 | positive regulation of viral genome replication |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.