Overview
| Uniprot ID | H0WE02 |
|---|
| Protein Name | Protein SET |
|---|
| Gene Name | - |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 24 |
SASPGLPKGEKEQQE |
Function
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher
Protein Sequence
10
MYAPYQYQSC
20
LVPRAASASP
30
GLPKGEKEQQ
40
EAIEHIDEVQ
50
NEIDRLNEQA
60
SEEILKVEQK
70
YNKLRQPFFQ
80
KRSELIAKIP
90
NFWVTTFVNH
100
PQVSALLGEE
110
DEEALHYLTR
120
VEVTEFEDIK
130
SGYRIDFYFD
140
ENPYFENKVL
150
SKEFHLNESG
160
DPSSKSTEIK
170
WKSGKDLTKR
180
SSQTQNKASR
190
KRQHEEPESF
200
FTWFTDHSDA
210
GADELGEVIK
220
DDIWPNPLQY
230
YLVPDMDDEE
240
GEGEEDDDDD
250
EEEEGLEDID
260
EEGDEDEGEE
270
DEDDDEGEEG
EEDEGEDD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Biological Process |
GO:0006334 |
nucleosome assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.