Search Results
Overview
| Uniprot ID | I3L397 |
|---|---|
| Protein Name | Eukaryotic translation initiation factor 5A |
| Gene Name | EIF5A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 68 | IDIFTGKKYEDICPS |
Function
Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step
Protein Sequence
10
MADDLDFETG
20
DAGASATFPM
30
QCSALRKNGF
40
VVLKGRPCKI
50
VEMSTSKTGK
60
HGHAKVHLVG
70
IDIFTGKKYE
80
DICPSTHNMD
90
VPNIKRNDFQ
100
LIGIQDGYLS
110
LLQDSGEVRE
120
DLRLPEGDLG
130
KEIEQKYDCG
140
EEILITVLSA
MTEEAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0043022 | ribosome binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003746 | translation elongation factor activity |
| Biological Process | GO:0045901 | positive regulation of translational elongation |
| Biological Process | GO:0045905 | positive regulation of translational termination |
Reference
PMID: N/A