Search Results
Overview
| Uniprot ID | I3L5E2 |
|---|---|
| Protein Name | Sorting nexin-17 |
| Gene Name | SNX17 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 409 | TMVKLSSKLSAVSLR |
Function
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P))
Protein Sequence
10
MHFSIPETES
20
RSGDSGGSAY
30
VLRKEYGANV
40
LPAFPPKKLF
50
SLTPAEVEQR
60
REQLEKYMQA
70
VRQDPLLGSS
80
ETFNSFLRRA
90
QQETQQVPTE
100
EVSLEVLLSN
110
GQKVLVNVLT
120
SDQTEDVLEA
130
VAAKLDLPDD
140
LIGYFSLFLV
150
REKEDGAFSF
160
VRKLQEFELP
170
YVSVTSLRSQ
180
EYKIVLRKSY
190
WDSAYDDDVM
200
ENRVGLNLLY
210
AQTVSDIERG
220
WILVTKQHRQ
230
LKSLQEKVSK
240
KEFLRLAQTL
250
RHYGYLRFDA
260
CVADFPEKDC
270
PVVVSAGNSE
280
LSLQLRLPGQ
290
QLREGSFRVT
300
RMRCWRVTSS
310
VPLPSGGTSS
320
PGRGRGEVRL
330
ELAFEYLMSK
340
DRLQWVTITS
350
PQAIMMSICL
360
QSMVDELMVK
370
KSGGSIRKML
380
RRRVGGTLRR
390
SDSQQAVKSP
400
PLLESPDASR
410
DTMVKLSSKL
420
SAVSLRGIGT
430
PSTDASASDV
440
HGNFAFEGIG
DEDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0015031 | protein transport |
| Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
| Cellular Component | GO:0005769 | early endosome |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.