Search Results

Overview

Uniprot IDI3L5Y0
Protein Nameprocollagen-proline 4-dioxygenase
Gene NameP4HA2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
144 MRLQDTYKLDPDTIS
300 LCRGEGVKLTPRRQK
370 RATVRDPKTGVLTVA
443 RPFDSGLKTEGNRLA
509 CPVLVGCKWVSNKWF

Function

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins

Protein Sequence

10 MKLQVSMLLV 20 AWFGVLNCVQ 30 AEFFTSIGHM 40 TDLIYAEKDL 50 VQSLKEYILV 60 EEAKLSKIKS 70 WASKMEALTS 80 QSAADPEGYL 90 AHPVNAYKLV 100 KRLNTDWPVL 110 EDLVLQDSAA 120 GFIANLSVQR 130 QFFPTDEDEA 140 GAAKALMRLQ 150 DTYKLDPDTI 160 SRGDLPGTKY 170 QAMLSVDDCF 180 GMGRSAYNEG 190 DYYHTVLWME 200 QVLKQLDAGE 210 EATTSKAQVL 220 DYLSYAVFQL 230 GDLHRALELT 240 RRLLSLDPGH 250 ERAGGNLRYF 260 ERLLEEEREK 270 MLSNHTEAGP 280 STPGGIYERP 290 VDYLPERDVY 300 ESLCRGEGVK 310 LTPRRQKRLF 320 CRYHHGNRTP 330 QLLIAPFKEE 340 DEWDSPHIVR 350 YYDVMSDEEI 360 ERIKEIAKPK 370 LARATVRDPK 380 TGVLTVASYR 390 VSKSSWLEED 400 DDPVVARVNR 410 RMQHITGLTV 420 KTAELLQVAN 430 YGMGGQYEPH 440 FDFSRRPFDS 450 GLKTEGNRLA 460 TFLNYMSDVE 470 AGGATVFPDL 480 GAAIWPKKGT 490 AVFWYNLLRS 500 GEGDYRTRHA 510 ACPVLVGCKW 520 VSNKWFHERG 530 QEFLRPCGST EVD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005788 endoplasmic reticulum lumen
Molecular Function GO:0005506 iron ion binding
Molecular Function GO:0031418 L-ascorbic acid binding
Molecular Function GO:0004656 procollagen-proline 4-dioxygenase activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.