Search Results

Overview

Uniprot IDI3L7B7
Protein NameATP-dependent RNA helicase
Gene NameDDX18
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
141 KETVVSGKVKKSLKQ
171 KETVGSGKVKKSRKE
234 KKKKKKRKIVDDAGP
340 RDLLAAAKTGSGKTL
468 EELKQIIKLLPTRRQ
486 FSATQTRKVEDLARI
497 LARISLKKEPLYVGV
687 QLEKLIEKNYFLHKS
776 RIFKHISKKPSDGRQ
82 KETVGSGKVKKSLKQ

Function

ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop. Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus

Protein Sequence

10 MSHLPMKLLR 20 KKIEKRNLKL 30 RQRNLKLQGT 40 LGVGLSETQN 50 GDVSEETMGD 60 GKVKKSLKQS 70 VNADLSETPN 80 GDISKETVGS 90 GKVKKSLKQS 100 MNVDLSETQS 110 GDISKTVGGG 120 KVKKSLKHSV 130 NVDLSETQNG 140 DVSKETVVSG 150 KVKKSLKQSV 160 NAGLSEAQNG 170 DISKETVGSG 180 KVKKSRKESV 190 NAGLSEAQNG 200 DVSKETGENV 210 KKPSKKSSIL 220 TSDEAATQSL 230 NSESKKKKKK 240 KKRKIVDDAG 250 PDSKKAKTED 260 KGEPGDSAQA 270 PEETENSMEK 280 PDKDDDTEVP 290 SLPLGLTGAF 300 EDTSFASLTD 310 LVNENTLRAI 320 KEMGFTNMTE 330 IQHKSIRPLL 340 EGRDLLAAAK 350 TGSGKTLAFL 360 IPAVELIVKL 370 RFMPRNGTGV 380 LILSPTRELA 390 MQTFGVLKEL 400 MTYHVHTYGL 410 IMGGSNRSAE 420 AQKLANGINI 430 VVATPGRLLD 440 HMQNTPGFMY 450 KNLQCLVIDE 460 ADRILDVGFE 470 EELKQIIKLL 480 PTRRQTMLFS 490 ATQTRKVEDL 500 ARISLKKEPL 510 YVGVDDDKAN 520 ATVDGLEQGY 530 VVCPSEKRFL 540 LLFTFLKKNR 550 KKKLMVFFSS 560 CKSVKYHYEL 570 LNYIDLPVLA 580 IHGRQKQNKR 590 TTTFFQFCNA 600 DSGILLCTDV 610 AARGLDIPEV 620 DWIVQYDPPD 630 DPKEYIHRVG 640 RTARGLNGRG 650 HALLILRPEE 660 LGFLRYLKQS 670 KVPLSEFEFS 680 WSKISDIQSQ 690 LEKLIEKNYF 700 LHKSAQEAYK 710 SYIRAYDSHS 720 LKQIFNVNNL 730 NLPQVALSFG 740 FKVPPFVDLN 750 VNSNDGKVKK 760 RGGGGGFGYQ 770 KAKKVEKSRI 780 FKHISKKPSD GRQFSH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003724 RNA helicase activity
Biological Process GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.