Search Results

Overview

Uniprot ID	I3L7K2
Protein Name	Phosphoinositide phospholipase C
Gene Name	PLCD1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
336	AYIRALCKGCRCLEL

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Binds phosphatidylinositol 4,5-bisphosphate

Protein Sequence

10 SCGGRDNQPT 20 QAGLQDDKDL 30 QALLKGGQLL 40 KVKSNSWRRE 50 RFYKLQEDCK 60 TIWQESRKVM 70 RTPESQLFSI 80 EDIQEVRMGH 90 RTEGLEKFAR 100 DVPEDRCFSI 110 VFKDQRNTLD 120 LIAPSPADAQ 130 HWVLGLRKII 140 HHSGSMDQRQ 150 KLQHWIHSCL 160 RKADKNKDNK 170 MSFKEVQNFL 180 KELNIQVDDS 190 YARKIFRECD 200 HSQTDSLEDE 210 EIETFYKMLT 220 QRKEIDRIFE 230 EAAGSEEALS 240 VDQLVAFLQH 250 QQQEEAAGPA 260 LALSLIERYE 270 PSETAKAQRQ 280 MTKDGFLMYL 290 LSADGSAFNL 300 AHRRVYQDMG 310 QPLSHYLVSS 320 SHNTYLLEDQ 330 LTGPSSTEAY 340 IRALCKGCRC 350 LELDCWDGPN 360 LEPIIYHGYT 370 FTSKILFCDV 380 LRAIRDYAFK 390 VGAPLGPGAA 400 ARDDRPLDGV 410 TTSLPSPEQL 420 KGKILLKGKK 430 LGGLFPPGGE 440 GSPEATVVSD 450 EDEAAEMEDE 460 AVRSRVQHKP 470 TEDKLRLVKE 480 LSDMVIYCKS 490 VHFRGFPSPG 500 TPGQAFYEMA 510 SFSENRALRL 520 LQESGDRIYP 530 AGWRTDSSNY 540 NPVEMWNSGC 550 QIVALNFQTP 560 GPEMDVYQGR 570 FQDNGACGYV 580 LKPAFLRDPN 590 SAFNSRALAQ 600 GPWWARKRLS 610 VRVISGQQLP 620 KVNKNKNSIV 630 DPKVTVEIHG 640 VGRDVASRQT 650 AVVTNNGFNP 660 WWDTEFEFEV 670 VVPELALVRF 680 VVEDYDASSK 690 NDFIGQSTIP 700 LSSLKQGYRH 710 VHLLSKNGDQ 720 YPSATLFVKV ALWD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0043168	anion binding
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:1901981	phosphatidylinositol phosphate binding
Molecular Function	GO:0120548	phosphatidylinositol phospholipase C activity
Molecular Function	GO:0004435	phosphatidylinositol-4,5-bisphosphate phospholipase C activity
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0016042	lipid catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.