Search Results

Overview

Uniprot ID	I3L7Q4
Protein Name	Pre-mRNA-processing factor 6
Gene Name	PRPF6
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
265	KKARLLLKSVRETNP
703	EAYNQGLKKCPHSTP

Function

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation

Protein Sequence

10 MDASQIHFHC 20 SHDRNSEIIL 30 NLQRTLKIKW 40 RISAYSSQAS 50 SHNPSAFNGY 60 AGSLFSSGPY 70 EKDDEEADAI 80 YAALDKRMDE 90 RRKERREQRE 100 KEEIEKYRME 110 RPKIQQQFSD 120 LKRKLAEVTE 130 EEWLSIPEVG 140 DARNKRQRNP 150 RYEKLTPVPD 160 SFFAKHLQTG 170 ENHTSVDPRQ 180 TQFGGLNTPY 190 PGGLNTPYPG 200 GMTPGLMTPG 210 TGELDMRKIG 220 QARNTLMDMR 230 LSQVSDSVSG 240 QTVVDPKGYL 250 TDLNSMIPTH 260 GGDINDIKKA 270 RLLLKSVRET 280 NPHHPPAWIA 290 SARLEEVTGK 300 LQVARNLIMK 310 GTEMCPKSED 320 VWLEAARLQP 330 GDTAKAVVAQ 340 AVRHLPQSVR 350 IYIRAAELET 360 DIRAKKRVLR 370 KALEHVPNSV 380 RLWKAAVELE 390 EPEDARIMLS 400 RAVECCPTSV 410 ELWLALARLE 420 TYENARKVLN 430 KARENIPTDR 440 HIWITAAKLE 450 EANGNTQMVE 460 KIIDRAITSL 470 RANGVEINRE 480 QWIQDAEECD 490 KAGSVATCQA 500 VMRAVIGIGI 510 EEEDRKHTWM 520 EDADSCVAHN 530 ALECARAIYA 540 YALQVFPSKK 550 SVWLRAAYFE 560 KNHGTRESLE 570 ALLQRAVAHC 580 PKAEVLWLMG 590 AKSKWLAGDV 600 PAARSILALA 610 FQANPNSEEI 620 WLAAVKLESE 630 NNEYERARRL 640 LAKARSSAPT 650 ARVFMKSVKL 660 EWVLGNLAAA 670 QELCEEALKH 680 YEDFPKLWMM 690 KGQIEEQEEL 700 MEKAREAYNQ 710 GLKKCPHSTP 720 LWLLLSRLEE 730 KIGQLTRARA 740 ILEKSRLKNP 750 KNPGLWLESV 760 RLEYRAGLKN 770 IASTLMAKAL 780 QECPSSGVLW 790 SEAIFLEARP 800 QRKTKSVDAL 810 KKCEHDPHVL 820 LAVAKLFWSE 830 RKITKAREWF 840 HRTVKIDSDL 850 GDAWAFFYKF 860 ELQHGTEEQR 870 EEVRRRCENA 880 EPRHGELWCA 890 TSKDITNWQR 900 KIGEILVLVA ARIRNPF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005681	spliceosomal complex
Biological Process	GO:0000398	mRNA splicing, via spliceosome

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.