Search Results
Overview
| Uniprot ID | I3L829 |
|---|---|
| Protein Name | Nuclear protein localization protein 4 homolog |
| Gene Name | NPLOC4 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | VQSPDGVKRITATKR |
| 188 | ETAATFLKKVAKEFG |
| 209 | SVYINRNKTGEIPAS |
| 225 | NKSLNLLKIKHGDLL |
| 277 | FLSRQDGKIYRSRDP |
| 336 | TGGADKGKFVALENI |
| 346 | ALENISCKIKSGCEG |
| 400 | RFLDFWRKTGNQHFG |
| 417 | YGRYTEHKDIPLGIR |
Function
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI
Protein Sequence
10
MLSLKYVCIS
20
SRCDVTFSSL
30
SPFPCDQVSG
40
TPGRADAPGP
50
ADLSAASLPR
60
VASGGARLRG
70
AQGAGGRAAQ
80
ARTVGGAGTR
90
CAAGTQLRGR
100
GARGARRARH
110
RTSRRWLPAA
120
KLERRWRRRR
130
EAGAGAEAGA
140
GAARPAGRQA
150
AAAAAARGSS
160
PETGAAAMAE
170
SIIIRVQSPD
180
GVKRITATKR
190
ETAATFLKKV
200
AKEFGFQNNG
210
FSVYINRNKT
220
GEIPASSNKS
230
LNLLKIKHGD
240
LLFLFPSSLA
250
GPSAEMETSA
260
PLALKACGAP
270
NVVEDDIDQF
280
LSRQDGKIYR
290
SRDPQLCRHG
300
PLGKCVHCVP
310
LEPFDEDYLN
320
HLEPPVKHMS
330
FHAYIRKLTG
340
GADKGKFVAL
350
ENISCKIKSG
360
CEGHLPWPNG
370
ICTKCQPSAI
380
TLNRQKYRHV
390
DNIMFENHTV
400
ADRFLDFWRK
410
TGNQHFGYLY
420
GRYTEHKDIP
430
LGIRAEVAAI
440
YEPPQIGTQN
450
SLELLEDPKA
460
EVVDEIAAKL
470
GLRKVGWIFT
480
DLVSEDARKG
490
TVRYSRNKDT
500
YFLSSEECIT
510
AGDFQNKHPN
520
VCRLSPDGHF
530
GSKFVTAVAT
540
GGPDNQVHFE
550
GYQVSNQCMA
560
LVRDECLLPC
570
KDAPELGYAK
580
ESSSEQYVPD
590
VFYKDIDKFG
600
NEITQLARPL
610
PVEYLIIDIT
620
TTFPKDPVYT
630
FSISQNPFPI
640
ENRDVLGETQ
650
DFHSLATYLS
660
QSTSSVFLDT
670
VSDFHLLLFL
680
VTNDVMPLQD
690
SISLLLEAVR
700
TRNEELAQTW
710
KKSEQWATIE
720
QLCSTVGVQL
730
PGLQEYGAVG
740
GPTHAASAAM
750
WACQHCTFMN
760
QPGTGHCEMC
SLPRT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030970 | retrograde protein transport, ER to cytosol |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.