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Overview

Uniprot ID	I3L8X3
Protein Name	Cell cycle checkpoint protein RAD17
Gene Name	RAD17
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
395	KSDAALSKSKRRQKP

Function

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation. Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites. May also serve as a sensor of DNA replication progression

Protein Sequence

10 MLLPEGELYF 20 NVLQVVYSGW 30 ELSKFIMSKT 40 FLRPKVSSTK 50 VTDWVDPSFD 60 DFSETTNIST 70 INATSLSVNN 80 SSLRRKKVPS 90 TLESRRSPTR 100 KRGNLSSSKQ 110 IYSLENSKEY 120 VSENEPWVDK 130 YKPETQHELA 140 VHKKKIEEVE 150 TWLKVEVLER 160 QPTQGGSILL 170 ITGPPGCGKT 180 ATIKILSKEH 190 GIQVQEWINP 200 VLPEFQKDDF 210 KEIFNPESSF 220 HIFPYQSQIA 230 VFKEFLLRAT 240 KYNKLQMLGD 250 DLTTDKKIIL 260 VEDLPNQFYR 270 DPHILHEVLR 280 RYVQVGRCPL 290 IFIISDSLSG 300 DNNHRLLFPK 310 EIQEECAISN 320 ISFNPVAPTI 330 MMKFLNRIVT 340 KEANKNGGKI 350 IVPDKTSLEL 360 LCQGCSGDIR 370 SAINSLQFSS 380 STGKNNLWPR 390 KKGTSSLKSD 400 AALSKSKRRQ 410 KPDRVFENQE 420 VQAIGGKDVS 430 LFLFRALGKI 440 LYCKRASVTE 450 LDSPRLPSHL 460 SEYERDTLLI 470 HPEEVVEMSH 480 MPGDLFNLYL 490 HQNYVDFFMD 500 VDDLVRASEF 510 LSFADILSGD 520 WNYRENCLAA 530 KALFSDFCLS 540 PVCLQTQLLP 550 YLALLTIPMR 560 NQAQISFIQD 570 IGRLPLKRHF 580 GRLKMEALTD 590 REHGMMDLDS 600 GDEAQLGGGQ 610 PTEEALGEPT 620 PSTEPEPELL 630 SLPLSQNSGS 640 ELPASQPRPF 650 SAQGDMEEED 660 MIIEDYESDG T

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0031389	Rad17 RFC-like complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003689	DNA clamp loader activity
Biological Process	GO:0000077	DNA damage checkpoint signaling
Biological Process	GO:0006281	DNA repair

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.