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Overview

Uniprot IDI3L918
Protein NameExportin-2
Gene NameCSE1L
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
19 TLTEYLKKTLDPDPT
414 KNPSVNWKHKDAAIY
416 PSVNWKHKDAAIYLV
596 QKLLAVSKNPSKPHF
821 IIIPEIQKVSGNVEK
828 KVSGNVEKKICAVGI
829 VSGNVEKKICAVGIT
85 IVEDEPNKICEADRV
923 HLAQSLHKLSTACPG

Function

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

Protein Sequence

10 MAMELSDANL 20 QTLTEYLKKT 30 LDPDPTIRRP 40 AEKFLESVEG 50 NQNYPLLLLT 60 LLEKSQDNVI 70 KVCASVTFKN 80 YIKRNWRIVE 90 DEPNKICEAD 100 RVAIKANIVH 110 LMLSSPEQIQ 120 KQLSDAISII 130 GREDFPQKWP 140 DLLTEMVNRF 150 QSGDFHVING 160 VLRTAHSLFK 170 RYRHEFKSNE 180 LWTEIKLVLD 190 AFALPLTNLF 200 KVCNNNLVVF 210 LNYLIFLICA 220 FILQDLPEFF 230 EDNMETWMNN 240 FHTLLTLDNK 250 LLQTDDEEEA 260 GLLELLKSQI 270 CDNAALYAQK 280 YDEEFQRYLP 290 RFVTAIWNLL 300 VTTGQEVKYD 310 LLVSNAIQFL 320 ASVCERPHYK 330 NLFEDQNTLT 340 SICEKVIVPN 350 MEFRAADEEA 360 FEDNSEEYIR 370 RDLEGSDIDT 380 RRRAACDLVR 390 GLCKFFEGPV 400 TGIFSGYVNS 410 MLQEYAKNPS 420 VNWKHKDAAI 430 YLVTSLASKA 440 QTQKHGITQA 450 NELVNLTEFF 460 VNHILPDLKS 470 ANVNEFPVLK 480 ADGIKYIMIF 490 RNQVPKEHLL 500 VSIPLLINHL 510 QAESIVVHTY 520 AAHALERLFT 530 MRGPNNATLF 540 TAAEIAPFVE 550 ILLTNLFKAL 560 TLPGSSENEY 570 IMKAIMRSFS 580 LLQEAIIPYI 590 PTLITQLTQK 600 LLAVSKNPSK 610 PHFNHYMFEA 620 ICLSIRITCK 630 ANPAAVVNFE 640 EALFLVFTEI 650 LQNDVQEFIP 660 YVFQVMSLLL 670 ETHKNDIPSS 680 YMALFPHLLQ 690 PVLWERTGNI 700 PALVRLLQAF 710 LERGSNTIAS 720 AAADKIPGLL 730 GVFQKLIASK 740 ANDHQGFYLL 750 NSIIEHMPPE 760 SVDQYRKQIF 770 ILLFQRLQNS 780 KTTKFIKSFL 790 VFINLYCIKY 800 GALALQEIFD 810 GIQPKMFGMV 820 LEKIIIPEIQ 830 KVSGNVEKKI 840 CAVGITKLLT 850 ECPPMMDTEY 860 TKLWTPLLQS 870 LIGLFELPED 880 DTIPDEEHFI 890 DIEDTPGYQT 900 AFSQLAFAGK 910 KEHDPVGQMV 920 NNPKIHLAQS 930 LHKLSTACPG 940 RVPSMVSTSL 950 NAEALQYLQG 960 YLQAASVTLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006886 intracellular protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.