Search Results
Overview
| Uniprot ID | I3L945 |
|---|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase |
| Gene Name | USP14 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 279 | SEEEEVTKGKENQLQ |
| 303 | KYLFTGLKLRLQEEI |
| 325 | QRNALYIKSSKISRL |
| 354 | EKESVNAKVLKDVKF |
| 399 | KKVNQQPKASDKKSS |
| 453 | GHYVSWVKRKQDEWI |
| 74 | DDDWGNIKIKNGMTL |
Function
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes
Protein Sequence
10
MPLYSGERPL
20
RLAPRTSVTV
30
KWGKEKFEGV
40
ELNTDEPPMV
50
FKAQLFALTG
60
VQPARQKVMV
70
KGGTLKDDDW
80
GNIKIKNGMT
90
LLMMGSADAL
100
PEEPSAKTVF
110
VEDMTEEQLA
120
SAMELPCGLT
130
NLGNTCYMNA
140
TVQCIRSVPE
150
LKDALKRYAG
160
ALRASGEMAS
170
AQYITAALRD
180
LFDSMDKTSS
190
SIPPIILLQF
200
LHMAFPQFAE
210
KGEQGQYLQQ
220
DANECWIQMM
230
RVLQQKLEAI
240
EDDTVKETDS
250
SSASAVTPSK
260
KKSLIDQFFG
270
VEFETTMKCT
280
ESEEEEVTKG
290
KENQLQLSCF
300
INQEVKYLFT
310
GLKLRLQEEI
320
TKQSPTLQRN
330
ALYIKSSKIS
340
RLPAYLTIQM
350
VRFFYKEKES
360
VNAKVLKDVK
370
FPLMLDVYEL
380
CTPELQEKMV
390
SFRSKFKDLE
400
DKKVNQQPKA
410
SDKKSSPQKE
420
VKYEPFSFAD
430
DIGSNNCGYY
440
DLQAVLTHQG
450
RSSSSGHYVS
460
WVKRKQDEWI
470
KFDDDKVSIV
480
TPEDILRLSG
490
GGDWHIAYVL
500
LYGPRRVEIM
EEESE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0000502 | proteasome complex |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Molecular Function | GO:0004866 | endopeptidase inhibitor activity |
| Molecular Function | GO:0070628 | proteasome binding |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:1904293 | negative regulation of ERAD pathway |
| Biological Process | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0071108 | protein K48-linked deubiquitination |
| Biological Process | GO:0050920 | regulation of chemotaxis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.