Search Results

Overview

Uniprot ID	I3L946
Protein Name	Neurolysin, mitochondrial
Gene Name	NLN
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
278	HYFPVMKKCCIPETR
365	REFILNLKKKECEEK

Function

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1

Protein Sequence

10 MFCSSIFTSV 20 IPWPASSRAL 30 QLPQKSNQSW 40 SWLTLPSRVG 50 GSGILLRMTL 60 GREAMSPLQA 70 MSSYTVDGRN 80 VLRWDLSPEQ 90 IKRRTEELIA 100 QTKQVYDDIG 110 MLDIEEVTYE 120 NCLQALADVE 130 VKYIVERTML 140 DFPQHVSSDK 150 EVRAASTEAD 160 KRLSRFDIEM 170 SMREDIFLRI 180 VRLKETCDLG 190 KIKPEARRYL 200 EKSVKMGKRN 210 GLHLPEQVQN 220 EIKAMKKRMS 230 ELCIDFNKNL 240 NEDDTFLVFS 250 KAELGALPDD 260 FIDSLEKTDD 270 NKYKITLKYP 280 HYFPVMKKCC 290 IPETRRKMEM 300 AFNTRCKEEN 310 TIILQELLPL 320 RAKVAKLLGY 330 STHADFVLEM 340 NTAKSTHHVT 350 AFLDDLSQKL 360 KPLGEAEREF 370 ILNLKKKECE 380 EKGFEYDGKI 390 NAWDLHYYMT 400 QTEELKYSVD 410 QEILKEYFPI 420 EVVTEGLLNI 430 YQELLGLSFE 440 QVTDAHVWNK 450 SVTLYTVKDK 460 ATGEVLGQFY 470 LDLYPREGKY 480 NHAACFGLQP 490 GCLLPDGSRM 500 MSVAALVVNF 510 SQPRAGRPSL 520 LRHDEVRTYF 530 HEFGHVMHQI 540 CAQTDFARFS 550 GTNVETDFVE 560 VPSQMLENWV 570 WDTDSLRRLS 580 KHYKDGSPIT 590 DDLLEKLVAS 600 RLVNTGLLTL 610 RQIVLSKVDQ 620 SLHTNTSLDA 630 ASEYAKYCTE 640 ILGVAATPGT 650 NMPATFGHLA 660 GGYDGQYYGY 670 LWSEVFSMDM 680 FYSCFKKEGI 690 MNPEVGMKYR 700 NLILKPGGSL 710 DGMDMLQNFL 720 KREPNQKAFL MSRGLHAP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005758	mitochondrial intermembrane space
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Molecular Function	GO:0042277	peptide binding
Biological Process	GO:0006508	proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.