Search Results
Overview
| Uniprot ID | I3L9F5 |
|---|---|
| Protein Name | Prenylcysteine oxidase 1 |
| Gene Name | PCYOX1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 263 | WAVKGGNKLVCSRLL |
| 292 | IEEKTRTKQTGNPTK |
| 66 | QKFGKDVKIDVFEKG |
| 72 | VKIDVFEKGEVGGRL |
Function
Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides. Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded
Protein Sequence
10
MKPLAGGLPC
20
FLTFGLWLGL
30
LLLCSWGCPG
40
SAAPRSPPEK
50
IAVIGAGIGG
60
TSAAYYLRQK
70
FGKDVKIDVF
80
EKGEVGGRLA
90
TLTMQGQEYE
100
SGGSIIHPLN
110
LHMKRFVKDL
120
GLSAVQSPSG
130
LVGVYNGETL
140
VYEESSWFII
150
NMIKLIWYYG
160
FQSLRMHMWV
170
EDILDKFMSL
180
FKRIYRYQSH
190
DYAFSSVEKL
200
LHSLGGDDFL
210
GLFNRSLLET
220
LQKAGFSEKF
230
LDEIITPVMR
240
VNYGQTMNIN
250
GFVGAVSMSC
260
TDPGLWAVKG
270
GNKLVCSRLL
280
QASKSNLISG
290
SVMSIEEKTR
300
TKQTGNPTKV
310
YEVVYQTGPE
320
IHSDFYDIVL
330
VATPLNQKMS
340
NITFLNFDPP
350
IEEFHQYYEP
360
LVTTLIKGQL
370
NSTVFSSRAL
380
DEFDLGTILT
390
TDNPDLFINS
400
IGLVSSVEEN
410
NNPQPKVERA
420
HVWKVFSAGP
430
LTKEQILKLF
440
VSYDYAVKQS
450
WLAYPHYTPP
460
EKCPSTILHD
470
QLYYLNGIEF
480
AASAMEMSAV
490
AGYNAALLAY
500
HRWNGHTHMI
510
DQEDLYEKLK
TEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0001735 | prenylcysteine oxidase activity |
| Biological Process | GO:0030327 | prenylated protein catabolic process |
| Biological Process | GO:0030328 | prenylcysteine catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.