Search Results
Overview
| Uniprot ID | I3L9V2 |
|---|---|
| Protein Name | NADPH-dependent quinone oxidoreductase VAT1 |
| Gene Name | VAT1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 232 | FGTASASKHEVLKEN |
| 284 | AKGYNLLKPMGKVII |
| 362 | LYNQGHIKPRIDSVW |
| 389 | QEKKNIGKVLLVPGP |
| 398 | LLVPGPEKEN***** |
| 68 | TGFGGYDKVKLQSRP |
Function
Multifunctional protein with enzymatic and transport activities. Probable NADPH-dependent quinone oxidoreductase which physiological substrates and function are unclear. Alternatively, has also been suggested to mediate the transfer of negatively charged phospholipids including phosphatidic acid (PA), phosphatidylserine (PS) and phosphatidylglycerol (PG) between endoplasmic reticulum and mitochondrial membranes. Could regulate mitochondrial fusion through its interaction with mitofusins
Protein Sequence
10
MSAEREVAEA
20
ATVVAAAEAG
30
AGEDASSQLP
40
KAEAAGDSQP
50
PAVSEGADSP
60
PLPPLRCLVL
70
TGFGGYDKVK
80
LQSRPAAPPA
90
PGPGQLTLRV
100
KACGLNFADL
110
MARQGLYDRL
120
PPLPITPGME
130
GAGVVIAVGE
140
GVEDRKVGDR
150
VMVLIRSGMW
160
QEEVTVPSAH
170
TFLMPEAMTF
180
EEAAALLVNY
190
ITAYMVLFDF
200
GNLRPGHSVL
210
VHMAAGGVGM
220
AALQLCRTVE
230
NVTVFGTASA
240
SKHEVLKENG
250
VTHPIDYHTT
260
DYVEEIKKIS
270
PKGVDIVMDP
280
LGGSDTAKGY
290
NLLKPMGKVI
300
IYGMANLLTG
310
PKRNLMALAR
320
TWWNQFSVSA
330
LQLLPANRAV
340
CGFHLGYLDG
350
EVELVSGVVA
360
RLVALYNQGH
370
IKPRIDSVWP
380
FEKVADAMRQ
390
MQEKKNIGKV
400
LLVPGPEKEN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Molecular Function | GO:0008753 | NADPH dehydrogenase (quinone) activity |
| Molecular Function | GO:0120014 | phospholipid transfer activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0120010 | intermembrane phospholipid transfer |
| Biological Process | GO:0010637 | negative regulation of mitochondrial fusion |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.