Search Results
Overview
| Uniprot ID | I3LA16 |
|---|---|
| Protein Name | mRNA cap guanine-N(7) methyltransferase |
| Gene Name | RNMT |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 119 | DGTQKKRKIELEDVP |
| 16 | ECEKLSLKEAKTSID |
| 262 | SKELLIDKFRDPEMC |
| 46 | PGTRLSEKAPTCGLV |
| 60 | VGTPKKRKMAFEDDL |
| 81 | CGEDTPSKKRKLDAG |
| 84 | DTPSKKRKLDAGIVP |
Function
Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC
Protein Sequence
10
MENSAKAEEC
20
EKLSLKEAKT
30
SIDSETESSF
40
SIDENTTSPG
50
TRLSEKAPTC
60
GLVGTPKKRK
70
MAFEDDLVKE
80
SSSCGEDTPS
90
KKRKLDAGIV
100
PEEKGSGDDE
110
GISRKRRMES
120
DDGTQKKRKI
130
ELEDVPEKRK
140
NLEEGHSSAV
150
AAHYNELQEV
160
GLEKRSQSRI
170
FYLRNFNNWM
180
KSVLIGEFLE
190
KVRQKKKRDI
200
TVLDLGCGKG
210
GDLLKWKKGR
220
IDKLVCTDIA
230
DVSVKQCQQR
240
YEDMKNRCRD
250
NEYIFSAEFI
260
TADCSKELLI
270
DKFRDPEMCF
280
DICSCQFVCH
290
YSFESYEQAD
300
IMLRNACERL
310
SPGGYFIGTT
320
PNSFELIRRL
330
EASETESFGN
340
EIYTVKFQKK
350
GDYPLFGCKY
360
DFNLEGVVDV
370
PEFLVYFPLL
380
NEMAKKYNMK
390
LVYQKTFLEF
400
YEEKIKNNEN
410
KMLLKRMQAL
420
EPYPASENSR
430
LASEKADDYE
440
HAAKYMKNSQ
450
VRLPLVSFHF
460
LTRIYLVFAF
EKQQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004482 | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| Molecular Function | GO:0003723 | RNA binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.