Search Results

Overview

Uniprot IDI3LA63
Protein NameMethionine--tRNA ligase, cytoplasmic
Gene NameMARS1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
158 YLVVQGKKGEDVLGP
413 TTTPQQTKITQDIFQ
480 LINAIELKKPQCKVC
494 CRSCPVVKSSRHLFL
505 HLFLDLPKLEKRLEE
775 IQVNEPWKRIKGSEA
872 RFGGGQAKVSPKPAV
915 LKAQKADKNQVAAEV
930 AKLLDLKKQLALAEG

Function

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus

Protein Sequence

10 MMGEIVYFRN 20 PGPGNSFSRN 30 SISRRAARQS 40 LIPLAGDRFR 50 LHQRGTHGEM 60 RLFVSEGAPG 70 SLPVLAAAGR 80 AQGRVELLIS 90 TVGPEECVVP 100 FLTRPKVPVL 110 QLDSGNYLFS 120 ASAICRYFFL 130 LSGWEQDDLT 140 NQWLEWEATE 150 LQPALSAALY 160 YLVVQGKKGE 170 DVLGPVRRAL 180 THIDHSLSRR 190 SCPFLAGETE 200 SLADIVLWGA 210 LYPLLQDPAY 220 LPEELGTLHS 230 WFQTLSSQEP 240 CQRAVETVLK 250 QQGVLALRPY 260 LQKQPQPSFL 270 EGRAVSNEPE 280 EEELATLSEE 290 EIAMAVAAWE 300 KGLGSLPPLR 310 PQQNPVLPVA 320 GERNVLITSA 330 LPYVNNVPHL 340 GNIIGCVLSA 350 DVFARYSRLR 360 QWNTLYLCGT 370 DEYGTATETK 380 AMEEGLTPQE 390 ICDKYHAVHA 400 DIYRWFNISF 410 DIFGRTTTPQ 420 QTKITQDIFQ 430 RLFTRGFVLQ 440 DTVEQLRCEH 450 CARFLADRFV 460 EGVCPFCGYE 470 EARGDQCDKC 480 GKLINAIELK 490 KPQCKVCRSC 500 PVVKSSRHLF 510 LDLPKLEKRL 520 EEWLEKTLPG 530 SDWTPNARFI 540 IRSWLRDGLK 550 PRCITRDLKW 560 GTPVPLEGFE 570 DKVFYVWFDA 580 TIGYLSITAN 590 YTDQWERWWK 600 NPEQVSLYQF 610 MAKDNVPFHG 620 LVFPCSALGT 630 EDNYTLVSHL 640 IATEYLNYED 650 GKFSKSRGVG 660 VFGDMAQNTG 670 IPADIWRFYL 680 LYIRPEGQDT 690 AFSWTDMLLK 700 NNSELLNNLG 710 NFINRAGMFV 720 SKFFGCFVPE 730 MVLTSDDRRL 740 LAHVTLELQH 750 YHQLLEKARI 760 RDALRSILTI 770 SRHGNQYIQV 780 NEPWKRIKGS 790 EADRQRAGTV 800 TGLAVNIAAL 810 LSVMLQPYMP 820 TVSATIQAQL 830 QLSPPACSIL 840 PTNFLCTLPA 850 GHQIGTVSPL 860 FQKLENDQIE 870 SLRQRFGGGQ 880 AKVSPKPAVV 890 ETVTTAGPQQ 900 VQVLMDEVTK 910 QGNIVRELKA 920 QKADKNQVAA 930 EVAKLLDLKK 940 QLALAEGKPF ETPKGKKKR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004825 methionine-tRNA ligase activity
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006431 methionyl-tRNA aminoacylation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.