Overview
| Uniprot ID | I3LAV9 |
|---|
| Protein Name | TOX high mobility group box family member 4 |
|---|
| Gene Name | TOX4 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 207 |
TVVVEAGKKQKAPKK |
Function
Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate. In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation. Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes. Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase
Protein Sequence
10
MEFPGGSDNY
20
LTITGPSHPF
30
LSGAETFHTP
40
SLGDEEFEIP
50
PISLDSDPSL
60
AVSDVVGHFD
70
DLADPSSSQD
80
GSFSAQYGVQ
90
TLDMPVGMTH
100
GLMEQGGGLL
110
SGGLTMDLDH
120
SIGTQYSANP
130
PVTIDVPMTD
140
MTSGLMGHSQ
150
LTTIDQSELS
160
SQLGLSLGGG
170
TILPPAQSPE
180
DRLSTTPSPT
190
SSLHEDGVEE
200
FRRQLPSQKT
210
VVVEAGKKQK
220
APKKRKKKDP
230
NEPQKPVSAY
240
ALFFRDTQAA
250
IKGQNPNATF
260
GEVSKIVASM
270
WDSLGEEQKQ
280
VYKRKTEAAK
290
KEYLKALAAY
300
KDNQECQATV
310
ETVELDPAPP
320
SQTPSPPPVA
330
TTADPASPAP
340
ATTEPPALSP
350
SIVVNSTLSS
360
YVTNQASSGA
370
GGQPNITKLI
380
ITKQMLPSSI
390
TMSQGGMVTV
400
IPATVVTSRG
410
LQLGQTSTAT
420
IQPSQQAQIV
430
TRSVLQAAAA
440
AAASMQLPPP
450
RLQPPPLQQM
460
PQPPTQQQVT
470
ILQQPPPLQA
480
MQQPPPQKFR
490
INLQQQPPPL
500
QVKIVPPPTL
510
KMQTTLVPPP
520
VENSPEQPMN
530
SSPEAHTVEE
540
TSPETICEMI
550
TDVVPEVESP
560
PQMDVELVDE
570
SPVTLSPQPR
580
CVRSGCENPP
590
VVSKDWDNEY
600
CSNECVVKHC
610
RDVFLAWVAS
620
RNSNTVVFVK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0031490 |
chromatin DNA binding |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.