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Overview

Uniprot IDI3LB64
Protein NameNucleolar protein 56
Gene NameNOP56
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
133 LHFHNLVKGLTDLSA
157 SYSRAKVKFNVNRVD
226 RRELNEEKLEKLEEL
241 TMDGAKAKAILDASR
374 ISRYLANKCSIASRI
511 GSLPKRKKSLSSPVS
86 LETHLPSKKKKVLLG
89 HLPSKKKKVLLGVGD

Function

Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs)

Protein Sequence

10 VLLHVLFEHA 20 VGYALLALKE 30 VEEISLLLPQ 40 VEECVLNLGK 50 FHNIVRLVAF 60 SPFSSSQVAL 70 ENANAVSEGV 80 VHEDLRLFLE 90 THLPSKKKKV 100 LLGVGDPKIG 110 AAIQEELGYN 120 CQTGGVIAEV 130 LRGVRLHFHN 140 LVKGLTDLSA 150 CKAQLGLGHS 160 YSRAKVKFNV 170 NRVDNMIIQS 180 ISLLDQLDKD 190 INTFSMRVRE 200 WYGYHFPELV 210 KIINDNATYC 220 RLAQFIGNRR 230 ELNEEKLEKL 240 EELTMDGAKA 250 KAILDASRSS 260 MGMDISAIDL 270 INIESFSSRV 280 VSLSEYRQSL 290 HTYLRSKMSQ 300 VAPSLSALIG 310 EAVGARLIAH 320 AGSLTNLAKY 330 PASTVQILGA 340 EKALFRALKT 350 RGNTPKYGLI 360 FHSTFIGRAA 370 AKNKGRISRY 380 LANKCSIASR 390 IDCFSEVPTS 400 VFGEKLREQV 410 EERLSFYETG 420 EIPRKNLEVM 430 KEAMVQAEEA 440 AAEITRKLEK 450 QEKKRLKKEK 460 KRLAAVALAS 470 SENSSSTPEE 480 CEETSERPKK 490 KKKKQKPQEE 500 ELVSSDLEER 510 AGSGSLPKRK 520 KSLSSPVSDP 530 EESGNKKIPK 540 KKRKLSPKEE 550 PLSSGPEEAA 560 VSKSSGSKKK 570 KKLQKLSQET

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031428 box C/D methylation guide snoRNP complex
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:0030515 snoRNA binding
Biological Process GO:0042254 ribosome biogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.