Search Results
Overview
| Uniprot ID | I3LBD8 |
|---|---|
| Protein Name | Semaphorin-3C |
| Gene Name | SEMA3C |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 285 | NKWTTFLKARLVCSV |
| 495 | TMKISSKKQQLYVSS |
Function
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance
Protein Sequence
10
MAYQAVWVFI
20
GVFVFSTCVK
30
GLFQPQARVY
40
LTFDELQETK
50
TSEYFSLSHH
60
PLDYRILLMD
70
EDQDRIYVGS
80
KDHILSLNIN
90
NITQEPLSVF
100
WPASTIKVEE
110
CKMAGKDPTH
120
GCGNFVRVIQ
130
AFNRTHLYVC
140
GSGAFSPVCT
150
YLNRGRRSED
160
QVFMIDSKCE
170
SGKGRCSFNP
180
SVNTVSVMIN
190
EELFSGMYID
200
FMGTDAAIFR
210
SLTKRNAVRT
220
DQHNSKWLSE
230
PMFVDAHVIP
240
DGTDPNDAKV
250
YFFFKEKLTD
260
NSRSTKQIHS
270
MIARICPNDT
280
GGLRSLVNKW
290
TTFLKARLVC
300
SVTDEDGPET
310
HFDELEDVFL
320
LETDNPRTTL
330
VYGIFTTSSS
340
VFKGSAVCVY
350
HLSDIQTVFN
360
GPFAHKEGPN
370
HQLISYQGRI
380
PYPRPGTCPG
390
GAFTPNMRTT
400
KEFPDDVVTF
410
IRNHPLMYNS
420
IYPIHRRPLI
430
VRIGTDYKYT
440
KIAVDRVNAA
450
DGRYHVLFLG
460
TNRGTVQKVV
470
VLPTNSSSSG
480
ELILEELEVF
490
KNHAPITTMK
500
ISSKKQQLYV
510
SSNEGLSQVS
520
LHRCHIYGTA
530
CADCCLARDP
540
YCAWDGHSCS
550
RFYPTGKRRS
560
RRQDVRHGNP
570
LTQCRGFNLK
580
AYRNAAELVQ
590
YGVKNNTTFL
600
ECAPKSPQAS
610
IKWLLQKDKD
620
RRKEVKLNER
630
IIATAQGLLI
640
RSVQDSDQGL
650
YHCIATENSF
660
KQTIAKINFK
670
VLDSEMVAVV
680
TDKWSPWTWA
690
SSVRALPFHP
700
KDIMGAFSHS
710
EMQMINQYCK
720
DTRQQHQQGG
730
ESQKMRGDYG
740
KLKALINSRK
750
SRNRRNQLPE
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0045499 | chemorepellent activity |
| Molecular Function | GO:0038191 | neuropilin binding |
| Molecular Function | GO:0030215 | semaphorin receptor binding |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0140074 | cardiac endothelial to mesenchymal transition |
| Biological Process | GO:0003215 | cardiac right ventricle morphogenesis |
| Biological Process | GO:0060174 | limb bud formation |
| Biological Process | GO:0050919 | negative chemotaxis |
| Biological Process | GO:0001755 | neural crest cell migration |
| Biological Process | GO:0021915 | neural tube development |
| Biological Process | GO:0003148 | outflow tract septum morphogenesis |
| Biological Process | GO:1905312 | positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0003350 | pulmonary myocardium development |
| Biological Process | GO:0071526 | semaphorin-plexin signaling pathway |
| Biological Process | GO:0001756 | somitogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.