Search Results
Overview
| Uniprot ID | I3LBQ6 |
|---|---|
| Protein Name | Activating signal cointegrator 1 complex subunit 1 |
| Gene Name | ASCC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 64 | QGFRCTVKAPSLLYK |
Function
Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction
Protein Sequence
10
MEVLRPQLLR
20
IGGRVYRKNP
30
IQEQTYQHEE
40
EDDDYYHGLM
50
ECAEEPCEAY
60
EVVQTPQGFR
70
CTVKAPSLLY
80
KHIVGKRGDT
90
RKKLEVETKT
100
SITIPKPGQE
110
GEIVITGQHR
120
SGVISARTRI
130
DVLLLTFRRK
140
QPFTHFLAFF
150
LNEVEVQERF
160
LKFQEEVLEK
170
CSMDHGVDST
180
IFQNPKKLHL
190
TIGMLVLLSE
200
QEIQQTCEML
210
QQCKEEFIDD
220
ISGGKPLEVE
230
MAGIEYMNDD
240
PGMVDVLYAK
250
VHMKDGSNRL
260
QELVDRVLER
270
FQASGLIVKE
280
WNSVKLHATV
290
MNTLFRKDPN
300
AEGRYNLYTA
310
DGKYIFKERE
320
SFDGRNILKG
330
SGTRNNDDIS
340
GTVQSSLGEC
350
EPQKALFPHY
360
RPADGRSSQP
370
AWPHPSALLQ
380
ALLGSASLTV
390
TPHLCLLTAF
400
LFPSFHSLIL
ILAVREV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006307 | DNA alkylation repair |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.