Overview
| Uniprot ID | I3LC07 |
|---|
| Protein Name | Ras-related protein Rab-18 |
|---|
| Gene Name | RAB18 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 138 |
VDRNEGLKFARKHSM |
| 186 |
ENQNKGVKLTHREEG |
| 48 |
IGVDFKVKTISVDGN |
| 56 |
TISVDGNKAKLAIWD |
| 58 |
SVDGNKAKLAIWDTA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration
Protein Sequence
10
MDEDVLTTLK
20
ILIIGESGVG
30
KSSLLLRFTD
40
DTFDPELAAT
50
IGVDFKVKTI
60
SVDGNKAKLA
70
IWDTAGQERF
80
RTLTPSYYRG
90
AQGVILVYDV
100
TRRDTFVKLD
110
NWLNELETYC
120
TRNDIVNMLV
130
GNKIDKENRE
140
VDRNEGLKFA
150
RKHSMLFIEA
160
SAKTCDGVQC
170
AFEELVEKII
180
QTPGLWESEN
190
QNKGVKLTHR
200
EEGQGGGACG
GYCSVL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0005811 |
lipid droplet |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0034389 |
lipid droplet organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.