Search Results

Overview

Uniprot ID	I3LCA2
Protein Name	T-complex protein 1 subunit theta
Gene Name	CCT8
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
138	GYEIACRKAHEILPD
152	DLVCCSAKNLRDVDE
20	QMLKEGAKHFSGLEE
37	YRNIQACKELAQTTR

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia

Protein Sequence

10 MALHVPKAPG 20 FAQMLKEGAK 30 HFSGLEEAVY 40 RNIQACKELA 50 QTTRTAYGPN 60 GMNKMVINHL 70 EKLFVTNDAA 80 TILRELEVQH 90 PAAKMIVMAS 100 HMQEQEVGDG 110 TNFVLVFAGA 120 LLELAEELLR 130 IGLSVSEVIE 140 GYEIACRKAH 150 EILPDLVCCS 160 AKNLRDVDEV 170 SSLLHTSVMS 180 KQYGNEAFLA 190 KLIAQACVSI 200 FPDSGHFNVD 210 NIRVCKILGS 220 GVLSSVLHGM 230 VFKKETEGDV 240 TSVKDAKIAV 250 YSCPFDGMIT 260 ETKGTVLIKT 270 AEELMNFSKG 280 EENLMEAQVK 290 AIADTGANVV 300 VTGGKVADMA 310 LHYANKYNIM 320 LVRLNSKWDL 330 RRLCKTVGAT 340 ALPRLTPPVL 350 EEMGHCDSVY 360 LSEVGDTQVV 370 VFKHEKEDGA 380 ISTIVLRGST 390 DNLMDDIERA 400 VDDGVNTFKV 410 LTRDKRLVPG 420 GGATEIELAK 430 QITSYGETCP 440 GLEQYAIKKF 450 AEAFESIPRA 460 LAENSGVKAN 470 EVISKLYAVH 480 QEGNKNVGLD 490 IEAEVPAVKD 500 MLEAGVLDTY 510 LGKYWAIKLA 520 TNAAVTVLRV 530 DQIIMAKPAG 540 GPKPPSGKKD WDDDQND

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005832	chaperonin-containing T-complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0140662	ATP-dependent protein folding chaperone
Molecular Function	GO:0051082	unfolded protein binding
Biological Process	GO:0006457	protein folding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.