Search Results
Overview
| Uniprot ID | I3LCI2 |
|---|---|
| Protein Name | Pyruvate dehydrogenase E1 component subunit alpha |
| Gene Name | PDHA1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 244 | AASTDYYKRGDFIPG |
| 313 | EIQEVRSKSDPIMLL |
| 371 | RGANQWIKFKSIS** |
| 63 | LTREDGLKYYRMMQT |
| 83 | LKADQLYKQKIIRGF |
Function
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Protein Sequence
10
MRKMLAAVSR
20
VLSGVAQKPA
30
SRVLVASRNF
40
ANDATFEIKK
50
CDLHRLEEGP
60
PVTTVLTRED
70
GLKYYRMMQT
80
VRRMELKADQ
90
LYKQKIIRGF
100
CHLCDGQEAC
110
CVGLEAGINP
120
TDHLITAYRA
130
HGFTFTRGLS
140
VREILAELTG
150
RRGGCGKGKG
160
GSMHMYAKNF
170
YGGNGIVGAQ
180
VPLGAGIALA
190
CKYNGKDEVC
200
LTLYGDGAAN
210
QGQIFEAYNM
220
AALWKLPCVF
230
ICENNRYGMG
240
TSVERAAAST
250
DYYKRGDFIP
260
GLRVDGMDIL
270
CVREATRFAA
280
AYCRSGKGPI
290
LMELQTYRYH
300
GHSMSDPGVS
310
YRTREEIQEV
320
RSKSDPIMLL
330
KDRMVNSNLA
340
SVEELKEIDV
350
EVRKEIEDAA
360
QFATADPEPP
370
LEVRGANQWI
KFKSIS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0006086 | pyruvate decarboxylation to acetyl-CoA |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.