Search Results
Overview
| Uniprot ID | I3LCW1 |
|---|---|
| Protein Name | Fatty acid synthase |
| Gene Name | FASN |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1152 | LAQALQTKVAQQGLK |
| 1702 | TTVGSAEKRAYLQAR |
| 1737 | VLRHTAGKGVDLVLN |
| 1833 | CTVFPRTKVEAAFRY |
| 1849 | AQGKHIGKVVIQVRE |
| 1909 | LRLRGAQKLVLTSRS |
| 2353 | YTQSVRAKMTPGCEA |
| 2425 | AARSFYQKLRAAENY |
| 41 | TADDRRWKAGLYGLP |
| 528 | LRSDQALKPLGLRVS |
| 673 | KREDVFVKEVRTGGI |
| 706 | RKVILDPKPRSKRWL |
Function
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain
Protein Sequence
10
MEEVVIAGMS
20
GKLPESENLE
30
EFWANLIGGV
40
DMVTADDRRW
50
KAGLYGLPRR
60
MGKLKDLSRF
70
DASFFGVHSK
80
QANTMDPQLR
90
MLLEVTYEAI
100
VDGGINPASL
110
RGTSTGVWVG
120
VSSSDASEAL
130
SRDPETLVGY
140
SMIGCQRAMM
150
ANRVSFFFDF
160
KGPSITIDTA
170
CSSSLLALQS
180
AYQAIRGGEC
190
SAAVVGGLNV
200
LLKPNSSLQF
210
MKLGMLSQDG
220
TCRSFDAEGT
230
GYCRAEAVVA
240
VLLTKKSLAR
250
RVYATILNAG
260
TNTDGSKEQG
270
VTFPSGDVQE
280
QLIRSLYAPA
290
GPDPESLEYI
300
EAHGTGTKVG
310
DPQELNGIVN
320
ALCATRREPL
330
LIGSTKSNMG
340
HPEPASGVAA
350
LIKVLLSLEH
360
GVWAPNLHYH
370
TPNPEIPALQ
380
DGRLQVVDRP
390
LPIRGGNVGI
400
NSFGFGGSNV
410
HVILQPNSRP
420
APPPAQHAAL
430
PRLLQASGRT
440
LEAVQTLLEQ
450
GLRHSRDLAF
460
VGMLNEIAAV
470
SPVAMPFRGY
480
AVLGGEAGSQ
490
EVQQVPGSKR
500
PVWFICSGMG
510
AQWQGMGLSL
520
MRLDRFRDSI
530
LRSDQALKPL
540
GLRVSDLLLS
550
TDEAVLDDIV
560
SSFVSLTSIQ
570
IALIDLLTSL
580
GLQPDGIIGH
590
SLGEVACGYA
600
DGCLTQEEAV
610
LSSYWRGYCI
620
KEANVLPGAM
630
AAVGLSWEEC
640
KQRCPPGIVP
650
ACHNSKDTVT
660
ISGPQAAMSE
670
FLQQLKREDV
680
FVKEVRTGGI
690
AFHSYFMESI
700
APTLLRQLRK
710
VILDPKPRSK
720
RWLSTSIPEA
730
QWQGSLARTF
740
SAEYSVNNLV
750
SPVLFQEALQ
760
HVPAHAVVVE
770
IAPHALLQAV
780
LKRSLESSCT
790
IIPLMKKDHR
800
DNLEFFLSNV
810
GRLHLAGVSV
820
NPNGLFPPVE
830
FPAPRTPLIS
840
PHIKWDHSQA
850
WDVPSAADFP
860
SGSSCSSVAV
870
YKFDVSPESP
880
DHYLVDHCID
890
GRVLFPGTGY
900
LWLTWKTLAR
910
ALSQNLEETP
920
VVFEDVTLHQ
930
ATILPKTGTV
940
SLEVRLLEAS
950
HAFEVSDSNG
960
SLIASGKVYQ
970
WESPDPKLFD
980
TRAAVDPADS
990
TAEFRLSQGD
1000
VYKDLRLRGY
1010
DYGPFFQLVL
1020
ESDLEGNRGR
1030
LQWNDSWVSF
1040
LDAMLHMSIL
1050
APGQLGLYLP
1060
TRFTSIRIDP
1070
VTHRQKLYTL
1080
QDTTQAADVV
1090
VDRNLNTVVA
1100
GGALFLGAHS
1110
SVAPRRPQEH
1120
LKPILEKFCF
1130
TPHVESGCLA
1140
GNTALQEELQ
1150
LCRGLAQALQ
1160
TKVAQQGLKM
1170
VVPGLDGAQA
1180
PREAPQQSLP
1190
RLLAAACQLQ
1200
LNGNLQLELG
1210
QVLAQERPLL
1220
CDDPLLSGLL
1230
DAPALKACVD
1240
TALENMASPK
1250
MKVVEVLAGD
1260
GQLYSRIPAL
1270
LNTQPVMDLD
1280
YTATDRNPQA
1290
LEAAQAKLEQ
1300
LHVTQGQWDP
1310
ANPAPGSLGK
1320
ADLLVCNCAL
1330
ATLGDPAVAV
1340
GNMAATLKEG
1350
FLLLHTLLAG
1360
HPLGEMVGFL
1370
TSPEQGGRHL
1380
LSQDQWESLF
1390
AGASLHLVAL
1400
KRSFYGSVLF
1410
LCRQQTPQDS
1420
PVFLSVEDTS
1430
FRWVNSLKDI
1440
LADASSRPVW
1450
LMAVGCSTSG
1460
VVGMVNCLRK
1470
EPGGHRIRCV
1480
LVSNLSSTSP
1490
APEMHPSSSE
1500
LQKVLQGDLV
1510
MNVYRDGAWG
1520
AFRHFPLEQD
1530
RPEKQTEHAF
1540
VNVLSRGDLS
1550
SIRWVCSPLH
1560
YALPASCQDR
1570
LCSVYYTSLN
1580
FRDVMLATGK
1590
LSPDSIPGKW
1600
LTRDCMLGME
1610
FSGRDASGRR
1620
VMGMVPAGGL
1630
ATSVLLLPHA
1640
TWEVPSTWTL
1650
EEAASVPIVY
1660
TTAYYSLVVR
1670
GRMQPGESVL
1680
IHSGSGGVGQ
1690
AAIAIALSRG
1700
CRVFTTVGSA
1710
EKRAYLQARF
1720
PQLDETCFAN
1730
SRDTSFEQHV
1740
LRHTAGKGVD
1750
LVLNSLAEEK
1760
LQASVRCLAQ
1770
HGRFLEIGKF
1780
DLSNNHALGM
1790
AVFLKNVTFH
1800
GILLDSLFEE
1810
GGATWQEVSE
1820
LLKAGIQEGV
1830
VQPLKCTVFP
1840
RTKVEAAFRY
1850
MAQGKHIGKV
1860
VIQVREEEQG
1870
PAPRGLPPIA
1880
LTGLSKTFCP
1890
PHKSYVITGG
1900
LGGFGLQLAQ
1910
WLRLRGAQKL
1920
VLTSRSGIRT
1930
GYQARQVREW
1940
RRQGVQVLVS
1950
TSNASSLDGA
1960
RSLITEATQL
1970
GPVGGVFNLA
1980
MVLRDAVLEN
1990
QTPEFFQDVS
2000
KPKYSGTANL
2010
DRVTREACPE
2020
LDYFVIFSSV
2030
SCGRGNAGQA
2040
NYGFANSAME
2050
RICEKRRHDG
2060
LPGLAVQWGA
2070
IGDVGVVLET
2080
MGTNDTVIGG
2090
TLPQRIASCL
2100
EVLDLFLSQP
2110
HPVLSSFVLA
2120
EKKAAAPRDG
2130
SSQKDLVKAV
2140
AHILGIRDVA
2150
SINPDSTLVD
2160
LGLDSLMGVE
2170
VRQILEREHD
2180
LVLSMREVRQ
2190
LSLRKLQELS
2200
SKTSTDADPA
2210
TPTSHEDSPV
2220
RQQATLNLST
2230
LLVNPEGPTL
2240
TRLNSVQSAE
2250
RPLFLVHPIE
2260
GSITVFHGLA
2270
AKLSIPTYGL
2280
QCTGAAPLDS
2290
IQSLASYYIE
2300
CIRQVQPEGP
2310
YRIAGYSYGA
2320
CVAFEMCSQL
2330
QAQQSATPGN
2340
HSLFLFDGSH
2350
TFVLAYTQSV
2360
RAKMTPGCEA
2370
EAEAKAMYFF
2380
VQQFTDMEQG
2390
KVLEALIPLQ
2400
GLEARVAATV
2410
DLITQSHAGL
2420
DRHALSFAAR
2430
SFYQKLRAAE
2440
NYWPQATYHG
2450
NVTLLRAKTG
2460
GAYGEDLGAD
2470
YNLSQVCDGK
2480
VSVHVIEGDH
2490
RTLLEGSGLE
2500
SILSIIHSCL
2510
AEPRVSVREG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0042587 | glycogen granule |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0019171 | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| Molecular Function | GO:0004316 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| Molecular Function | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| Molecular Function | GO:0004313 | [acyl-carrier-protein] S-acetyltransferase activity |
| Molecular Function | GO:0004314 | [acyl-carrier-protein] S-malonyltransferase activity |
| Molecular Function | GO:0141148 | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| Molecular Function | GO:0004312 | fatty acid synthase activity |
| Molecular Function | GO:0016297 | fatty acyl-[ACP] hydrolase activity |
| Molecular Function | GO:0031177 | phosphopantetheine binding |
| Biological Process | GO:0008611 | ether lipid biosynthetic process |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0044788 | host-mediated perturbation of viral process |
| Biological Process | GO:0030879 | mammary gland development |
| Biological Process | GO:0030224 | monocyte differentiation |
| Biological Process | GO:0030223 | neutrophil differentiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.