Search Results

Overview

Uniprot IDI3LCW1
Protein NameFatty acid synthase
Gene NameFASN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1152 LAQALQTKVAQQGLK
1702 TTVGSAEKRAYLQAR
1737 VLRHTAGKGVDLVLN
1833 CTVFPRTKVEAAFRY
1849 AQGKHIGKVVIQVRE
1909 LRLRGAQKLVLTSRS
2353 YTQSVRAKMTPGCEA
2425 AARSFYQKLRAAENY
41 TADDRRWKAGLYGLP
528 LRSDQALKPLGLRVS
673 KREDVFVKEVRTGGI
706 RKVILDPKPRSKRWL

Function

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain

Protein Sequence

10 MEEVVIAGMS 20 GKLPESENLE 30 EFWANLIGGV 40 DMVTADDRRW 50 KAGLYGLPRR 60 MGKLKDLSRF 70 DASFFGVHSK 80 QANTMDPQLR 90 MLLEVTYEAI 100 VDGGINPASL 110 RGTSTGVWVG 120 VSSSDASEAL 130 SRDPETLVGY 140 SMIGCQRAMM 150 ANRVSFFFDF 160 KGPSITIDTA 170 CSSSLLALQS 180 AYQAIRGGEC 190 SAAVVGGLNV 200 LLKPNSSLQF 210 MKLGMLSQDG 220 TCRSFDAEGT 230 GYCRAEAVVA 240 VLLTKKSLAR 250 RVYATILNAG 260 TNTDGSKEQG 270 VTFPSGDVQE 280 QLIRSLYAPA 290 GPDPESLEYI 300 EAHGTGTKVG 310 DPQELNGIVN 320 ALCATRREPL 330 LIGSTKSNMG 340 HPEPASGVAA 350 LIKVLLSLEH 360 GVWAPNLHYH 370 TPNPEIPALQ 380 DGRLQVVDRP 390 LPIRGGNVGI 400 NSFGFGGSNV 410 HVILQPNSRP 420 APPPAQHAAL 430 PRLLQASGRT 440 LEAVQTLLEQ 450 GLRHSRDLAF 460 VGMLNEIAAV 470 SPVAMPFRGY 480 AVLGGEAGSQ 490 EVQQVPGSKR 500 PVWFICSGMG 510 AQWQGMGLSL 520 MRLDRFRDSI 530 LRSDQALKPL 540 GLRVSDLLLS 550 TDEAVLDDIV 560 SSFVSLTSIQ 570 IALIDLLTSL 580 GLQPDGIIGH 590 SLGEVACGYA 600 DGCLTQEEAV 610 LSSYWRGYCI 620 KEANVLPGAM 630 AAVGLSWEEC 640 KQRCPPGIVP 650 ACHNSKDTVT 660 ISGPQAAMSE 670 FLQQLKREDV 680 FVKEVRTGGI 690 AFHSYFMESI 700 APTLLRQLRK 710 VILDPKPRSK 720 RWLSTSIPEA 730 QWQGSLARTF 740 SAEYSVNNLV 750 SPVLFQEALQ 760 HVPAHAVVVE 770 IAPHALLQAV 780 LKRSLESSCT 790 IIPLMKKDHR 800 DNLEFFLSNV 810 GRLHLAGVSV 820 NPNGLFPPVE 830 FPAPRTPLIS 840 PHIKWDHSQA 850 WDVPSAADFP 860 SGSSCSSVAV 870 YKFDVSPESP 880 DHYLVDHCID 890 GRVLFPGTGY 900 LWLTWKTLAR 910 ALSQNLEETP 920 VVFEDVTLHQ 930 ATILPKTGTV 940 SLEVRLLEAS 950 HAFEVSDSNG 960 SLIASGKVYQ 970 WESPDPKLFD 980 TRAAVDPADS 990 TAEFRLSQGD 1000 VYKDLRLRGY 1010 DYGPFFQLVL 1020 ESDLEGNRGR 1030 LQWNDSWVSF 1040 LDAMLHMSIL 1050 APGQLGLYLP 1060 TRFTSIRIDP 1070 VTHRQKLYTL 1080 QDTTQAADVV 1090 VDRNLNTVVA 1100 GGALFLGAHS 1110 SVAPRRPQEH 1120 LKPILEKFCF 1130 TPHVESGCLA 1140 GNTALQEELQ 1150 LCRGLAQALQ 1160 TKVAQQGLKM 1170 VVPGLDGAQA 1180 PREAPQQSLP 1190 RLLAAACQLQ 1200 LNGNLQLELG 1210 QVLAQERPLL 1220 CDDPLLSGLL 1230 DAPALKACVD 1240 TALENMASPK 1250 MKVVEVLAGD 1260 GQLYSRIPAL 1270 LNTQPVMDLD 1280 YTATDRNPQA 1290 LEAAQAKLEQ 1300 LHVTQGQWDP 1310 ANPAPGSLGK 1320 ADLLVCNCAL 1330 ATLGDPAVAV 1340 GNMAATLKEG 1350 FLLLHTLLAG 1360 HPLGEMVGFL 1370 TSPEQGGRHL 1380 LSQDQWESLF 1390 AGASLHLVAL 1400 KRSFYGSVLF 1410 LCRQQTPQDS 1420 PVFLSVEDTS 1430 FRWVNSLKDI 1440 LADASSRPVW 1450 LMAVGCSTSG 1460 VVGMVNCLRK 1470 EPGGHRIRCV 1480 LVSNLSSTSP 1490 APEMHPSSSE 1500 LQKVLQGDLV 1510 MNVYRDGAWG 1520 AFRHFPLEQD 1530 RPEKQTEHAF 1540 VNVLSRGDLS 1550 SIRWVCSPLH 1560 YALPASCQDR 1570 LCSVYYTSLN 1580 FRDVMLATGK 1590 LSPDSIPGKW 1600 LTRDCMLGME 1610 FSGRDASGRR 1620 VMGMVPAGGL 1630 ATSVLLLPHA 1640 TWEVPSTWTL 1650 EEAASVPIVY 1660 TTAYYSLVVR 1670 GRMQPGESVL 1680 IHSGSGGVGQ 1690 AAIAIALSRG 1700 CRVFTTVGSA 1710 EKRAYLQARF 1720 PQLDETCFAN 1730 SRDTSFEQHV 1740 LRHTAGKGVD 1750 LVLNSLAEEK 1760 LQASVRCLAQ 1770 HGRFLEIGKF 1780 DLSNNHALGM 1790 AVFLKNVTFH 1800 GILLDSLFEE 1810 GGATWQEVSE 1820 LLKAGIQEGV 1830 VQPLKCTVFP 1840 RTKVEAAFRY 1850 MAQGKHIGKV 1860 VIQVREEEQG 1870 PAPRGLPPIA 1880 LTGLSKTFCP 1890 PHKSYVITGG 1900 LGGFGLQLAQ 1910 WLRLRGAQKL 1920 VLTSRSGIRT 1930 GYQARQVREW 1940 RRQGVQVLVS 1950 TSNASSLDGA 1960 RSLITEATQL 1970 GPVGGVFNLA 1980 MVLRDAVLEN 1990 QTPEFFQDVS 2000 KPKYSGTANL 2010 DRVTREACPE 2020 LDYFVIFSSV 2030 SCGRGNAGQA 2040 NYGFANSAME 2050 RICEKRRHDG 2060 LPGLAVQWGA 2070 IGDVGVVLET 2080 MGTNDTVIGG 2090 TLPQRIASCL 2100 EVLDLFLSQP 2110 HPVLSSFVLA 2120 EKKAAAPRDG 2130 SSQKDLVKAV 2140 AHILGIRDVA 2150 SINPDSTLVD 2160 LGLDSLMGVE 2170 VRQILEREHD 2180 LVLSMREVRQ 2190 LSLRKLQELS 2200 SKTSTDADPA 2210 TPTSHEDSPV 2220 RQQATLNLST 2230 LLVNPEGPTL 2240 TRLNSVQSAE 2250 RPLFLVHPIE 2260 GSITVFHGLA 2270 AKLSIPTYGL 2280 QCTGAAPLDS 2290 IQSLASYYIE 2300 CIRQVQPEGP 2310 YRIAGYSYGA 2320 CVAFEMCSQL 2330 QAQQSATPGN 2340 HSLFLFDGSH 2350 TFVLAYTQSV 2360 RAKMTPGCEA 2370 EAEAKAMYFF 2380 VQQFTDMEQG 2390 KVLEALIPLQ 2400 GLEARVAATV 2410 DLITQSHAGL 2420 DRHALSFAAR 2430 SFYQKLRAAE 2440 NYWPQATYHG 2450 NVTLLRAKTG 2460 GAYGEDLGAD 2470 YNLSQVCDGK 2480 VSVHVIEGDH 2490 RTLLEGSGLE 2500 SILSIIHSCL 2510 AEPRVSVREG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0042587 glycogen granule
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Molecular Function GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
Molecular Function GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
Molecular Function GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity
Molecular Function GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity
Molecular Function GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity
Molecular Function GO:0004312 fatty acid synthase activity
Molecular Function GO:0016297 fatty acyl-[ACP] hydrolase activity
Molecular Function GO:0031177 phosphopantetheine binding
Biological Process GO:0008611 ether lipid biosynthetic process
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0044788 host-mediated perturbation of viral process
Biological Process GO:0030879 mammary gland development
Biological Process GO:0030224 monocyte differentiation
Biological Process GO:0030223 neutrophil differentiation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.