Search Results
Overview
| Uniprot ID | I3LDH3 |
|---|---|
| Protein Name | Poly [ADP-ribose] polymerase |
| Gene Name | PARP1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | GQDGVGSKAEKTLGD |
| 119 | DFAAEYAKSNRSTCK |
| 15 | LYRVEYAKSGRASCK |
| 346 | FREITYLKKLKIKKQ |
| 400 | MKILTLGKLSRNKDE |
| 414 | EVKAAIEKLGGKLTG |
| 425 | KLTGTASKASLCVST |
| 433 | ASLCVSTKKEVDKMS |
| 502 | EAVAPRGKSGGALPK |
| 509 | KSGGALPKKSKGPIR |
| 522 | IREEGANKSEKRMKL |
| 583 | LQLLEDDKESRYWIF |
| 636 | WHSKNFTKYPKKFYP |
| 640 | NFTKYPKKFYPLEID |
| 943 | KHASHISKLPKGKHS |
Function
Promotes AIFM1-mediated apoptosis. This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis
Protein Sequence
10
MAESSDKLYR
20
VEYAKSGRAS
30
CKKCSESIPK
40
DSLRMAIMVQ
50
SPMFDGKVPH
60
WYHFSCFWKV
70
GHAIRHPDIE
80
VDGFSELRWD
90
DQQKVKKTAE
100
AGGVTGKGQD
110
GVGSKAEKTL
120
GDFAAEYAKS
130
NRSTCKGCME
140
KIEKGHVRLS
150
KKMLDPEKPQ
160
LGMIDRWYHP
170
NCFVQNREEL
180
GFRPEYSASQ
190
LKGFSLLTAE
200
DKEALKKQLP
210
GIKSEGKRKG
220
DEVDGVDGVA
230
KKKSKKEKDK
240
ESKLEKALKA
250
QNDLIWNIKD
260
ELKKVCSTND
270
LKELLIFNKQ
280
QVPSGESAIL
290
DRVADGMVFG
300
ALLPCEECSG
310
QLVFKSDAYY
320
CTGDVTAWTK
330
CMVKTQTPNR
340
KEWVTPKEFR
350
EITYLKKLKI
360
KKQDRIFPPE
370
ASTPVATAPP
380
PPAASAPTAV
390
NSSAPPDKPL
400
SNMKILTLGK
410
LSRNKDEVKA
420
AIEKLGGKLT
430
GTASKASLCV
440
STKKEVDKMS
450
KKMEEVKEAN
460
VRVVSEDFLQ
470
DVSASTKSLQ
480
ELLCTHILSP
490
WGAEMKAEVK
500
AEPVEAVAPR
510
GKSGGALPKK
520
SKGPIREEGA
530
NKSEKRMKLT
540
LKGGAAVDPD
550
SGLEHSAHVL
560
EKGGKVFSAT
570
LGLVDIVKGT
580
NSYYKLQLLE
590
DDKESRYWIF
600
RSWGRVGTVI
610
GSNKLEQMPS
620
KEDAIDHMKL
630
YEEKTGNAWH
640
SKNFTKYPKK
650
FYPLEIDYGQ
660
DEEAVKKLTV
670
NPGTKSKLPK
680
SVQELIKMIF
690
DVESMKKAMV
700
EYEIDLQKMP
710
LGKLSKRQIQ
720
AAYAILSEVQ
730
QAVSQGSSDS
740
QILDLSNRFY
750
TLIPHDFGMK
760
KPPLLNNADS
770
VQAKVEMLDN
780
LLDIEVAYSL
790
LRGGSDDSSK
800
DPIDVNYEKL
810
KTDIKVVDRD
820
SEEAETIRKY
830
VKNTHATTHN
840
AYDLEVIDIF
850
KIEREGESQR
860
YKPFKQLHNR
870
RLLWHGSRTT
880
NFAGILSQGL
890
RIAPPEAPVT
900
GYMFGKGIYF
910
ADMVSKSANY
920
CHTSQGDPIG
930
LILLGEVALG
940
NMYELKHASH
950
ISKLPKGKHS
960
VKGLGKTTPD
970
PAASITMDGV
980
EVPLGTGIPS
990
GVNDTCLLYN
1000
EYIVYDIAQV
1010
NLKYLLKLKF
NFKTSLW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:2001170 | negative regulation of ATP biosynthetic process |
| Biological Process | GO:0160049 | negative regulation of cGAS/STING signaling pathway |
| Biological Process | GO:0045824 | negative regulation of innate immune response |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0034244 | negative regulation of transcription elongation by RNA polymerase II |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0032786 | positive regulation of DNA-templated transcription, elongation |
| Biological Process | GO:1905168 | positive regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0070213 | protein auto-ADP-ribosylation |
| Biological Process | GO:0071168 | protein localization to chromatin |
| Biological Process | GO:0070212 | protein poly-ADP-ribosylation |
| Biological Process | GO:1905051 | regulation of base-excision repair |
| Biological Process | GO:0071932 | replication fork reversal |
| Biological Process | GO:0000012 | single strand break repair |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0043596 | nuclear replication fork |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0032993 | protein-DNA complex |
| Cellular Component | GO:0035861 | site of double-strand break |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0140294 | NAD DNA ADP-ribosyltransferase activity |
| Molecular Function | GO:0003950 | NAD+ poly-ADP-ribosyltransferase activity |
| Molecular Function | GO:0140816 | NAD+-histone H2BS6 serine ADP-ribosyltransferase activity |
| Molecular Function | GO:0140817 | NAD+-histone H3S10 serine ADP-ribosyltransferase activity |
| Molecular Function | GO:0140806 | NAD+-protein-aspartate ADP-ribosyltransferase activity |
| Molecular Function | GO:0140807 | NAD+-protein-glutamate ADP-ribosyltransferase activity |
| Molecular Function | GO:0140815 | NAD+-protein-histidine ADP-ribosyltransferase activity |
| Molecular Function | GO:0140808 | NAD+-protein-tyrosine ADP-ribosyltransferase activity |
| Molecular Function | GO:0044378 | non-sequence-specific DNA binding, bending |
| Molecular Function | GO:0031491 | nucleosome binding |
| Molecular Function | GO:0016779 | nucleotidyltransferase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:1990165 | single-strand break-containing DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:1990966 | ATP generation from poly-ADP-D-ribose |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0034644 | cellular response to UV |
| Biological Process | GO:0030592 | DNA ADP-ribosylation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006302 | double-strand break repair |
| Biological Process | GO:0071169 | establishment of protein localization to chromatin |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.