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Overview

Uniprot IDI3LDU9
Protein NameBeta-2-syntrophin
Gene NameSNTB2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
188 QALKRAGKEVLLEVK
329 AGGSKEVKHIAWLAE

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN

Protein Sequence

10 MRVAAPTAAA 20 GAGPAMAVWT 30 RATKAGLVEL 40 LLRERWVRVV 50 AELSGESLSL 60 TGDAAAAEPE 70 PALGPAAAAF 80 NGLPNGGGAG 90 DSLPGSPSRG 100 LGPPSPPAPP 110 RGPASEAGAS 120 PPVRRVRVVK 130 QEAGGLGISI 140 KGGRENRMPI 150 LISKIFPGLA 160 ADQSRALRLG 170 DAILSVNGTD 180 LRQATHDQAV 190 QALKRAGKEV 200 LLEVKFIREV 210 TPYIKKPSLV 220 SDLPWEGAAP 230 QSPSFSGSED 240 SGSPKHQNST 250 KDRKVIPLKM 260 CFAARNLSMP 270 TWKTGELLIE 280 LHSPDSRNTL 290 ILRCKDTATA 300 HSWFVAIHTN 310 IMALLPQVLA 320 ELNAMLGATS 330 TAGGSKEVKH 340 IAWLAEQAKL 350 DGGRQQWRPV 360 LMAVTEKDLL 370 LYDCMPWTRD 380 AWASPCHSYP 390 LVATRLVHSG 400 SGCRSPSLGS 410 DLTFATRTGS 420 RQGIEMHLFR 430 VETHRDLSTW 440 TRILVQGCHA 450 AAELIKEVSL 460 GCTLNGQEVR 470 LTVHYESGFT 480 ISRENGGSSS 490 ILYRYPFERL 500 KMSADDGIRN 510 LYLDFGGPEG 520 ELTMDLHSCP 530 KPIVFVLHTF 540 LSAKVTRMGL LV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070161 anchoring junction
Cellular Component GO:0016010 dystrophin-associated glycoprotein complex
Cellular Component GO:0005874 microtubule
Cellular Component GO:0045202 synapse
Cellular Component GO:0030658 transport vesicle membrane
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0005198 structural molecule activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.