Search Results
Overview
| Uniprot ID | I3LE68 |
|---|---|
| Protein Name | Tissue factor |
| Gene Name | F3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | DEIMRNVKETYVARV |
| 196 | ASSTGKKKATTNTNE |
| 230 | PSRRVNQKSPESRIE |
| 243 | IECTSQEKAVSRELF |
| 78 | SPRLGDWKNKCFHTT |
| 80 | RLGDWKNKCFHTTDT |
Function
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade
Protein Sequence
10
MATPTGPPVS
20
CPKAAVARAL
30
LLGWVLVQVA
40
GATGTTDVIV
50
AYNLTWKSTN
60
FKTILEWEPK
70
PINYVYTVQI
80
SPRLGDWKNK
90
CFHTTDTECD
100
VTDEIMRNVK
110
ETYVARVLSY
120
PADTVLTAQE
130
PPFTNSPPFT
140
PYLDTNLGQP
150
VIQSFEQVGT
160
KLNVTVEAAR
170
TLVRVNGTFL
180
RLRDVFGKDL
190
NYTLYYWRAS
200
STGKKKATTN
210
TNEFLIDVDK
220
GENYCFSVQA
230
VIPSRRVNQK
240
SPESRIECTS
250
QEKAVSRELF
260
LIVGAVVFAV
270
IVFVLVLSVS
280
LYKCRKERAG
290
PSGKENAPLN
VA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1905286 | serine-type peptidase complex |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004896 | cytokine receptor activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Biological Process | GO:0002543 | activation of blood coagulation via clotting cascade |
| Biological Process | GO:0002541 | activation of plasma proteins involved in acute inflammatory response |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0019221 | cytokine-mediated signaling pathway |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:2000353 | positive regulation of endothelial cell apoptotic process |
| Biological Process | GO:0001938 | positive regulation of endothelial cell proliferation |
| Biological Process | GO:0010641 | positive regulation of platelet-derived growth factor receptor signaling pathway |
| Biological Process | GO:0050927 | positive regulation of positive chemotaxis |
| Biological Process | GO:0032008 | positive regulation of TOR signaling |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.