Search Results
Overview
| Uniprot ID | I3LEI8 |
|---|---|
| Protein Name | Acireductone dioxygenase |
| Gene Name | ADI1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 73 | IITICRDKLPNYEEK |
Function
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14
Protein Sequence
10
MVQAWYMDES
20
ADDPRLPHRT
30
EPARPVGLDQ
40
LRRLGVLYWK
50
LDADKYENDP
60
ELEKIRNERN
70
YSWMDIITIC
80
RDKLPNYEEK
90
IKTFYEEHLH
100
LDDEIRYILD
110
GSGYFDVRDQ
120
DDRWIRIFME
130
KGDLITLPAG
140
IYHRFTLDEQ
150
NYVKAMRLFV
160
GDPVWTPYNR
170
PADHLEARGQ
YLRFLAQST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0010308 | acireductone dioxygenase (Ni2+-requiring) activity |
| Molecular Function | GO:0010309 | acireductone dioxygenase [iron(II)-requiring] activity |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0016151 | nickel cation binding |
| Biological Process | GO:0019509 | L-methionine salvage from methylthioadenosine |
| Biological Process | GO:0006555 | methionine metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.