Search Results

Overview

Uniprot IDI3LEY6
Protein NameTripeptidyl-peptidase 2
Gene NameTPP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1148 RGLKFATKLVEEKPT
1153 ATKLVEEKPTKENWK
1156 LVEEKPTKENWKNCI

Function

Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis. Stimulates adipogenesis

Protein Sequence

10 MATAATEEPF 20 PFHGLLPKKE 30 TGAASFLCRY 40 PEYDGRGVLI 50 AVLDTGVDPG 60 APGMQVTTDG 70 KPKIIDIIDT 80 TGSGDVNTAT 90 VAEPKDGELI 100 GLSGRVLKIP 110 ASWTNPSGRY 120 HIGIKNGYDF 130 YPKALKERIQ 140 KERKEKIWDP 150 VHRVALAEAC 160 RKQEEFDVAN 170 SCPSQVGASC 180 FDANKLIKEE 190 LQSQVELLNS 200 FEKKYSDPGP 210 VYDCLVWHDG 220 ETWRACIDSN 230 EDGDLSKSTV 240 LRNYKEAQEY 250 GSFGTAEMLN 260 YSVNIYDEGN 270 LLSIVTSGGA 280 HGTHVASIAA 290 GHFPEEPERN 300 GVAPGAQILS 310 IKIGDTRLST 320 METGTGLIRA 330 MIEVINHKCD 340 LVNYSYGEAT 350 HWPNSGRICE 360 VISEAVWKHN 370 IIYVSSAGNN 380 GPCLSTVGCP 390 GGTTSSVIGV 400 GAYVSPDMMV 410 AEYSLREKLP 420 ANQYTWSSRG 430 PSADGALGVS 440 ISAPGGAIAS 450 VPNWTLRGTQ 460 LMNGTSMSSP 470 NACGGIALIL 480 SGLKANNADY 490 TVHSVRRALE 500 NTAVKADNIE 510 VFAQGHGIIQ 520 VDKAYDYLVQ 530 NTSFANKLGF 540 TVTVGNNRGI 550 YLRDPIQVAA 560 PSDHGVGIEP 570 VFPENTENSE 580 KISLQLHLAL 590 TSNSSWVQCP 600 SHLELMNQCR 610 HINIRVDPRG 620 LREGLHYTEV 630 CGYDTASPNA 640 GPLFRVPITA 650 VIAAKVNESS 660 HYDLAFTDVH 670 FKPGQIRRHF 680 IEVPEGATWA 690 EVTVCSCSSE 700 VSAKFVLHAV 710 QLVKQRAYRS 720 HEFYKFCSLP 730 EKGTLTEAFP 740 VLGGKAIEFC 750 IARWWASLSD 760 VNIDYTISFH 770 GIVCTAPQLN 780 IHASEGINRF 790 DVQSSLKYED 800 LAPCITLKSW 810 VQTLRPLSAK 820 TKPLGSRDVL 830 PNNRQLYEMI 840 LTYNFHQPKS 850 GEVTPSCPLL 860 CELLYESEFD 870 SQLWIIFDQN 880 KRQMGSGDAY 890 PHQYSLKLEK 900 GDYTIRLQIR 910 HEQISDLERL 920 KDLPFIVSHR 930 LSNTLSLDIH 940 ENHSLALLGK 950 KKSSNLTLPP 960 KYNQPFFVTS 970 LPDDKIPKGA 980 GPGCYLSGSL 990 TLSKTELGKK 1000 AGQSAAKRQG 1010 KFKKDVIPVH 1020 YYLISPPTKT 1030 KNGSKDKDKD 1040 SEKEKDLKEE 1050 FTEALRDLKI 1060 QWMTNDMDKQ 1070 KSTLVDALCR 1080 KGCALADHLL 1090 QAQEQEGAVS 1100 SDAEGREEEG 1110 EGTLDSLTET 1120 FWETTKWTDL 1130 FDSKVLTFAY 1140 KHALVNKMYG 1150 RGLKFATKLV 1160 EEKPTKENWK 1170 NCIQLMKLLG 1180 WTHCASFTEN 1190 WLPIMYPPDY CVF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004177 aminopeptidase activity
Molecular Function GO:0004252 serine-type endopeptidase activity
Molecular Function GO:0008240 tripeptidyl-peptidase activity
Biological Process GO:0006508 proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.