Overview
| Uniprot ID | I3LGA2 |
|---|
| Protein Name | Lysophosphatidylserine lipase ABHD12 |
|---|
| Gene Name | ABHD12 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 37 |
LDADCRLKQNLCLAG |
Function
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding
Protein Sequence
10
MRKRAEPVAL
20
EHERRAVSGS
30
PSAGSAASAL
40
DADCRLKQNL
50
CLAGPGPAEP
60
RCASDAGMKR
70
ALGRRKGLCF
80
RLRKILLCVL
90
GLYVAIPFLI
100
KLCPAIQAKL
110
IFLNFVRVPY
120
FIDLKKPQDQ
130
GLNHTCNYYL
140
HPEEGVTIGV
150
WHTVPAVWWK
160
NAQGKDQIWY
170
EDALASSRPI
180
ILYLHGNAGT
190
RGGDHRVELY
200
KVLSSLGYHV
210
VTFDYRGWGD
220
SVGTPSERGM
230
TYDALHVFDW
240
IKARSGDNPV
250
YIWGHSLGTG
260
VATNLVRRLC
270
ERETPPDALI
280
LESPFTNIRE
290
EAKSHPFSVI
300
YRYFPGFDWF
310
FLDPITSSGI
320
QFANDENVKH
330
ISCSLLILHA
340
EDDPVVPFQL
350
GRKLYSIAAP
360
SRSFRDFKVQ
370
FIPFHSDLGY
380
RHKYIYKSPE
390
LPRILREFLG
KSEPAA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0032281 |
AMPA glutamate receptor complex |
| Cellular Component |
GO:0032839 |
dendrite cytoplasm |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0047372 |
monoacylglycerol lipase activity |
| Molecular Function |
GO:0008474 |
palmitoyl-(protein) hydrolase activity |
| Molecular Function |
GO:0004622 |
phosphatidylcholine lysophospholipase A1 activity |
| Molecular Function |
GO:0120560 |
phosphatidylserine lysophospholipase A1 activity |
| Biological Process |
GO:0052651 |
monoacylglycerol catabolic process |
| Biological Process |
GO:0006660 |
phosphatidylserine catabolic process |
| Biological Process |
GO:0050727 |
regulation of inflammatory response |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.