Overview
| Uniprot ID | I3LHX0 |
|---|
| Protein Name | EARP and GARP complex-interacting protein 1 |
|---|
| Gene Name | EIPR1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 254 |
CGDDCRVKFWDTRKV |
| 86 |
VLATCYNKTADSKVL |
Function
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex. Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles. Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes
Protein Sequence
10
MEDDAPVIYG
20
LEFQARALTP
30
QTAETDAIRF
40
LVGTQSLKYD
50
NQIHIIDFDD
60
ENNIINKNVL
70
LHRAGEIWHI
80
SASPADKGVL
90
ATCYNKTADS
100
KVLTCAAVWR
110
MPAELEPGGH
120
ESPEDAASPA
130
HALELLCHLD
140
HPARGSTACV
150
AWEPAGDGKR
160
VISLADNHLL
170
LWDLQESSSQ
180
ALLASSASLE
190
GKGQLKFTTG
200
RWSPHHSCTQ
210
VATANDTAVR
220
GWDTRTMSQI
230
YCIENAHGQL
240
VRDLDFNPNK
250
QYCLASCGDD
260
CRVKFWDTRK
270
VTEPVRTLEE
280
HSHWVWNVRY
290
NHSHDQLVLT
300
ASSDSRVILS
310
NMASISSEPF
320
GHLVDDDDLS
330
DQEERRPEEK
340
SQEPPQDSVI
350
ATYEEHEDSV
360
YAVEWAAADP
370
WLFASLSYDG
380
RLVVNRVPRA
LKYRILL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:1990745 |
EARP complex |
| Cellular Component |
GO:0000938 |
GARP complex |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005802 |
trans-Golgi network |
| Biological Process |
GO:2001137 |
positive regulation of endocytic recycling |
| Biological Process |
GO:1905281 |
positive regulation of retrograde transport, endosome to Golgi |
| Biological Process |
GO:0016567 |
protein ubiquitination |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.